Elsevier

Thrombosis Research

Volume 201, May 2021, Pages 23-29
Thrombosis Research

Incidence and impact of disseminated intravascular coagulation in COVID-19 a systematic review and meta-analysis

https://doi.org/10.1016/j.thromres.2021.02.010Get rights and content

Highlights

  • DIC was associated with the severity and poor prognosis of COVID-19 patients.

  • The incidence of DIC was higher in severe patients/ICU patients compared with Non-severe patients/Non-ICU patients.

  • The incidence of DIC in the subgroup using ISTH criteria was higher than the subgroup using non-ISTH criteria.

Abstract

Objectives

Coronavirus disease 2019 (COVID-19) is a novel infectious disease, with significant morbidity and mortality. This meta-analysis is to evaluate the prevalence of disseminated intravascular coagulation (DIC) in COVID-19 patients and to determine the association of DIC with the severity and prognosis of COVID-19.

Methods

We searched the PubMed, EMBASE, and China National Knowledge Infrastructure (CNKI) database until August 12, 2020. The meta-analysis was performed using Stata 16.0 software.

Results

14 studies were included in our meta-analysis. The pooled analysis revealed that the incidence of COVID-19 patients developing DIC was 3% (95%: 1%–5%, P < 0.001). In addition, deaths were more likely to be associated with DIC (Log OR = 2.46, 95% CI: 0.94–3.99, P < 0.001) with statistical significance.

Conclusions

DIC is associated with the severity and poor prognosis of COVID-19 patients. Therefore, attention should be paid to coagulation dysfunction in COVID-19 patients. Monitoring of coagulation indicators may improve the prognosis of COVID-19 inpatients.

Abbreviations

DIC
disseminated intravascular coagulation
COVID-19
coronavirus disease 2019
APTT
activated partial thromboplastin time
PT
prothrombin time
FDP
fibrin degradation products
CRP
C-reactive protein

Keywords

Coronavirus disease 2019 (COVID-19)
SARS-CoV-2
Disseminated intravascular coagulation

Cited by (0)

1

These authors contributed equally.

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