Vitamin DDoes Vitamin D Affect Risk of Developing Autoimmune Disease?: A Systematic Review
Section snippets
Methods
We searched the PubMed database from inception through April 2010 restricted to English language and human studies with the following search terms “vitamin D AND”; “autoimmune disease”; “autoimmunity”; “rheumatoid arthritis”; “spondylitis”; “spondyloarthropathy”; “psoriatic arthritis”; “systemic lupus erythematosis”; “scleroderma”; “systemic sclerosis”; “myositis”; “dermatomyositis”; “polymyositis”; “vasculitis”; “polymyalgia rheumatica”; “type 1 diabetes”; “multiple sclerosis”; “autoimmune
Results
We identified 1446 potentially relevant studies through our literature search and sorted and reviewed them as in Figure 1. Two hundred forty-two were immediately excluded as irrelevant to this review, leaving 1204 that were reviewed in further detail. Basic science and in vitro studies, genetic studies, ecological studies, and studies of biomarkers of inflammation were reviewed and summarized in the text. The human epidemiologic studies were sorted into epidemiologic studies of vitamin D levels
Conclusions
Understanding of the pluripotent immunomodulating and anti-inflammatory effects of vitamin D is advancing. Despite the in vitro and animal evidence for vitamin D's potential to decrease systemic inflammation and prevent autoimmune disease in humans, there remains insufficient human data to firmly support the hypothesis that vitamin D intake is related to the risk of developing autoimmune disease. Data from laboratory studies and cross-sectional and observational epidemiologic investigations
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2021, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :Clinically observed were also elevated concentrations of 1,25-dihydroxyvitamin D (1,25(OH)2D3, the biologically active form of vitamin D) in presence of tuberculosis infections and some forms of lymphoma [13,14]. Moreover, 1,25(OH) 2D3, has been shown to exert effects on the differentiation of dendritic cells (DCs), macrophages, and CD4+CD25+ regulatory T-cells [15–17]. Alteration of the inflammatory activity in the vasculature are described as one core mechanism in the onset and progression of arterial hypertension [18].
Vitamin D receptor rs2228570 and rs1544410 genetic polymorphisms frequency in Iraqi thalassemia patients compared to other ethnic populations
2021, Gene ReportsCitation Excerpt :The gene encoded for vitamin D receptor - has multiplied genetic polymorphisms (Nejentsev et al., 2004) - has a title role in the expression of 1, 25 dihydroxyvitamin D gene (Muncie and Campbell, 2009) VDR situated on the chromosome 12 q12 – q14, consisting of 11 exons with size 75 kb. The fourth important single nucleotide polymorphisms (SNPs) of VDR gene located in exon 2 and the 3′UTR region are VDR rs7975232 (Apa-I G > T), VDR rs731236 (Taq-I T > C), VDR rs2228570 (Bsm-I G > A) and VDR rs1544410 (Fok-I T > C) (Walters, 1992; Kriegel et al., 2011). Even though in most of these sites there was no change in the sequence of the encoded amino acids, only the influence effect of these sites on the functions of VDR still unclear, but it may reduce the VDR mRNA activity or stability (Karray et al., 2012; Morrison et al., 1997).
The VITamin D and OmegA-3 TriaL (VITAL) is being conducted by our research group at Brigham and Women's Hospital, Harvard Medical School (PI: JoAnn E. Manson, MD, DrPH). VITAL is funded by the National Institutes of Health (National Cancer Institute, National Heart Lung and Blood Institute, and other institutes and agencies are cosponsors (5U01CA138962)). The VITAL ancillary study on autoimmune disease incidence is funded by the National Institute of Arthritis and Musculoskeletal Diseases (R01 AR059086) and is being conducted by Karen H. Costenbader, MD, MPH (PI) and colleagues at Brigham and Women's Hospital, Harvard Medical School. Study vitamin D supplements are donated by Pharmavite LLC of Northridge, California.