Original articleComparison of Different Spectral Domain Optical Coherence Tomography Scanning Areas for Glaucoma Diagnosis
Section snippets
Methods
This diagnostic, case-control study included participants in a prospective, longitudinal study designed to evaluate optic nerve structure and visual function in glaucoma (Diagnostic Innovations in Glaucoma Study) conducted at the Hamilton Glaucoma Center, University of California, San Diego. Participants in the Diagnostic Innovations in Glaucoma Study include normal subjects, patients with glaucoma, and glaucoma suspects, who are longitudinally evaluated clinically and with several functional
Results
Of the 46 normal subjects and 107 glaucoma patients who had imaging with RTVue, 2 normal subjects and 1 glaucoma patient were excluded because of the baseline disc drawing not being consistent with the scan in both eyes, leaving 74 eyes of 44 normal subjects and 140 eyes of 106 glaucoma patients for the analysis.
Age, ethnicity, and visual field parameters of the 2 groups of participants are shown in Table 1. Patients in the glaucoma group were significantly older than the subjects in the normal
Discussion
To our knowledge, this is the first study to compare the diagnostic accuracies of the different RTVue scanning protocols for glaucoma. We found that RNFL thickness and GCC parameters had good performance to discriminate healthy eyes from those with glaucomatous visual field loss and performed significantly better than ONH parameters.
The RNFL thickness parameter with best diagnostic performance was the inferior quadrant thickness, with an AUC of 0.884 and a sensitivity of 71.4% for a specificity
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Cited by (0)
Manuscript no. 2009-1274.
Financial Disclosure(s): Linda M. Zangwill – Grant/Financial Support - Heidelberg Engineering, Carl Zeiss, Optovue
Robert N. Weinreb – Consultant, Grant/Financial Support - Optovue, Topcon, Carl Zeiss; Grant/Financial Support - Heidelberg Engineering
Pamela A. Sample – Grant/Financial Support - Carl Zeiss, Heidelberg Engineering, Welch Allyn
Felipe A. Medeiros – Consultant, Grant/Financial Support - Carl Zeiss; Lecture Fees - Heidelberg Engineering
Supported in part by NEI EY08208 (PAS), NEI EY11008 (LMZ), Participant retention incentive grants in the form of glaucoma medication at no cost (Alcon Laboratories Inc., Allergan, Pfizer Inc., SANTEN Inc.).