Clinical StudyIrreversible Electroporation for Nonthermal Tumor Ablation in the Clinical Setting: A Systematic Review of Safety and Efficacy
Section snippets
Materials and Methods
This review was written according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for reporting systematic reviews (17). The reviewers agreed to the terminology suggested by the Society of Interventional Radiology (SIR) in “Image-Guided Tumor Ablation: Standardization of Terminology and Reporting Criteria” (18).
Results
The searches identified 232 hits in PubMed and 353 in EMBASE. After removal of duplicates and exclusion based on title and abstract, 26 remaining articles were reviewed. The final analysis included 16 full-text articles (Fig 2). The articles were published between August 2010 and November 2013. Six articles were case reports and 10 were case series. The quality assessment summary scores of the included studies are shown in Figure 3. The entire list of ratings for each study is available in
Discussion
Intentional cell death induced by IRE for tumor ablation has been studied in recent years. Extensive preclinical testing of the potential advantage of preservation of extracellular matrix structures in the absence of thermal coagulation was performed before IRE was introduced in the clinical setting. The results found in this review are discussed further here.
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None of the authors have identified a conflict of interest.
Appendices A and B are available online at www.jvir.org.