The Journal of Steroid Biochemistry and Molecular Biology
Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women☆
Introduction
Established determinants of vitamin D status, as measured by serum 25-hydroxyvitamin D (25(OH)D) are exposure to sunlight and intake of vitamin D, either from foods or vitamin supplements [1], [2], [3]. Decreased physical activity (PA) and obesity and low social status have also been associated with low vitamin D levels in Europe and the USA [4], [5], [6]. The aim of the present study was to investigate predictors of vitamin D status within a large non-elderly population of healthy men and women living across the USA.
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Materials and methods
The subjects in this study were healthy controls, age-matched to case distributions, selected for five case–control studies of serum vitamin D and cancer nested within the original Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO) cohort. The PLCO Cancer Screening Trial is a large randomized controlled multicenter trial in the United States of approximately 155 000 men and women at sites in Birmingham, AL; Denver, CO; Detroit, MI; Honolulu, HI; Marshfield, WI; Minneapolis, MN;
Results
Descriptive characteristics of the population by 25(OH)D level are presented in Table 1. There was very little overt clinical vitamin D deficiency in this study population, with only 3% of the population having serum 25(OH)D <25 nmol/L; 12%, 29%, 79% and 95% had levels of serum 25(OH)D <37 nmol/L, <50 nmol/L, <80 nmol/L, <100 nmol/L, respectively. The average age was 63 ± 5 years (males (M): 64 ± 5 years; females (F): 63 ± 5 years), 6% were of non-Caucasian origin, 8% were current smokers and 36% had
Discussion
Our observation that 25(OH)D serum levels are higher in summer and autumn than in winter and spring is consistent with studies where date of blood draw has been ascertained [17], [18]. Mean serum 25(OH)D levels in our study of middle-aged men and women (men = 60.8 nmol/L; women = 65.4 nmol/L) were similar to the overall mean data from the latest US National Health and Nutrition Examination Survey (men = 62.9 nmol/L; women = 61.5 nmol/L) [19] and higher than most European studies [20], [21], [22], [23], [24]
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Factors affecting vitamin D status in outpatients with abdominal aortic aneurysm and peripheral artery disease- a single centre study
2021, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :The prevalence of VD deficiency in stroke survivors in a single-center study from Poland was 88.3% [32]. Stroke-related disability and lack of long-distance walks resulting in lower skin exposure to the sun combine with low sea fish consumption in Poland and are probably explaining this phenomenon [28,33,34]. To sum up, the patients with AAA do not have more prominent VD deficiency than patients with other clinical forms of atherosclerosis.
Relationship of sedentary time, physical activity and fitness with 1,25-dihydroxyvitamin D in middle-aged sedentary adults: The FIT-AGEING study
2021, Experimental GerontologyCitation Excerpt :Indeed, several studies have suggested that low levels of vitamin D are associated with numerous non-skeletal disorders, such as cardiovascular diseases (Ginde et al., 2009; Manousopoulou et al., 2015; Souberbielle et al., 2010), certain types of cancers (Garland et al., 2006), and others age-related diseases (Holick, 2012). It has been shown that higher PA levels are associated with higher vitamin D levels in different populations (Brock et al., 2010; da Silva et al., 2019; Giovannucci et al., 2006; Hibler et al., 2016; Pasco et al., 2009; Skaaby et al., 2016), but there are controversial findings regarding the relationship of sedentary behaviour and vitamin D levels (da Silva et al., 2019; Hibler et al., 2016; Thuesen et al., 2012). Vitamin D status has been usually defined as serum 25-hydroxyvitamin D levels [25(OH)D].
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Special issue selected article from the 14th Vitamin D Workshop held at Brugge, Belgium on October 4–8, 2009.