Regular Research ArticleThe Effect of Exercise Training on Cognitive Function in Older Adults with Mild Cognitive Impairment: A Meta-analysis of Randomized Controlled Trials
Section snippets
Data Sources and Searches
We performed a systematic review consistent with the preferred reporting items for systematic reviews (PRISMA).18 An electronic database search was originally performed in June 2012 and updated in December 2012 using Medline (1996–first week December 2012), EMBASE (1980–first week December 2012), CINAHL (1980–first week December 2012), PEDro (first week December), SPORTSDICUS (first week December), PsychInfo (1806–first week December 2012), PubMed (first week December 2012). The exercise
Results
Results of the search strategy are presented in Figure 1. The combined search yielded 7,294 potentially eligible papers, was reduced to 102 after reviewing titles and abstracts, which were reviewed in full to determine suitability. Fourteen RCTs met criteria, comprising 1,695 subjects with MCI, with three trials including individuals with documented MCI,24, 27, 28 two with diagnosis of amnestic-MCI,26, 29 and one with memory impairments and memory complaint with MMSE within normal limits.30 The
Conclusions
This systematic review identified 14 RCT trials of exercise in individuals with MCI. The quality of this literature was moderate, and the majority of trials had samples too small for sufficient power to detect small effects. The vast majority of outcomes (92%) were nonsignificant, providing no strong or consistent evidence that exercise of any particular type significantly or robustly improves cognition in individuals at risk of dementia with MCI.
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