Journal of Allergy and Clinical Immunology
Asthma outcomes: Quality of life
Section snippets
Definition
Asthma-related QOL, as an outcome measure, refers to the perceived impact of asthma on a patient’s (ie, respondent’s) QOL. As noted, several constructs have historically been included in QOL measures: health status (eg, symptom levels), functional status (eg, activity capabilities or impairments), and the patient’s perception of the impact of these impairments on his or her QOL. Other functional domains and symptomatology, such as emotional well-being, depression or anxiety, and social
Review of asthma-related QOL instruments
Descriptive summaries of 9 asthma-related QOL instruments for adult study populations and 4 instruments for pediatric study populations follow. The subcommittee does not recommend any instrument as a core instrument because findings from the subcommittee’s review of asthma QOL instruments revealed the following limitations: most instruments include measures of functional and health status or consist entirely of these measures; none of the instruments measures the full range of dimensions that
Summary
The Asthma Bother Profile (ABP) is a 22-item instrument requiring 10 minutes to complete that was developed for the primary purpose of clinical management of patients and not necessarily for use as an outcome measure in clinical studies. The ABP is designed to assess adult patients’ perception of the asthma experience and distress in different situations and areas of life, as well as patients’ perception of their asthma management. This asthma QOL instrument is unique among currently available
Asthma-related QOL instruments for pediatric study populations
QOL instruments developed for adults are not appropriate for use with children. There are several special considerations in developing pediatric instruments that have been described as the “4 Ds of childhood”: developmental change, dependence on adults, different disease epidemiology from adults, and demographic characteristics unique to childhood.10 Because of these challenges, pediatric QOL instruments are relatively less developed than adult instruments, but a growing number of pediatric
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2022, Allergology InternationalCitation Excerpt :This may be due to the fact that exacerbation was relatively infrequent in the present study (median 1.0–1.5 events per three years). Nevertheless, exacerbations definitely have a negative impact on QoL in patients with asthma,17,21 therefore, prevention of exacerbations through maintenance of asthma control levels is critical in the management of severe asthma. On the other hand, exposure to external factors such as viral upper respiratory tract infections, pollen, and environmental factors is often associated with the development of exacerbations, and pollen exposure exacerbates asthma symptoms and reduces asthma control and QoL during specific seasons.1,56,57
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The Asthma Outcomes workshop was funded by contributions from the National Institute of Allergy and Infectious Diseases; the National Heart, Lung, and Blood Institute; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; the National Institute of Environmental Health Sciences; the Agency for Healthcare Research and Quality; and the Merck Childhood Asthma Network, as well as by a grant from the Robert Wood Johnson Foundation. Contributions from the National Heart, Lung, and Blood Institute; the National Institute of Allergy and Infectious Diseases; the Eunice Kennedy Shriver National Institute of Child Health and Human Development; the National Institute of Environmental Health Sciences; and the US Environmental Protection Agency funded the publication of this article and all other articles in this supplement.
Disclosure of potential conflict of interest: M. D. Cabana is on the Merck speaker’s bureau and is a consultant for Genentech and Pfizer. M. B. Foggs is a consultant and speaker for AstraZeneca, GlaxoSmithKline, and Merck. L. Olson participated in the development of the Children’s Health Survey for Asthma (CHSA) as a member of the AAP staff. The rest of the authors declare that they have no relevant conflicts of interest.