Asthma diagnosis and treatmentThe Canadian Childhood Asthma Primary Prevention Study: Outcomes at 7 years of age
Section snippets
Study population
The cohort has been described in previous reports.6, 7 Briefly, infants at high risk for asthma development, defined as those with at least one first-degree relative with asthma or 2 first-degree relatives with other IgE-mediated allergic diseases (atopic dermatitis, seasonal or perennial allergic rhinitis, or food allergy), were identified during the mother's third trimester of pregnancy. Families were randomly allocated to our multifaceted intervention (n = 279) or to the control group (n = 266).
Results
The characteristics at baseline of the 380 children who returned for an interview and physical examination at 7 years of age are shown in Table I. Except for a greater percentage of mothers in the control group having postsecondary education, personal and family characteristics at baseline of those who came in for interview and examination at 7 years of age were not different from the characteristics of those who only completed a questionnaire over the telephone and also were not different from
Discussion
This is a study of the outcomes at 7 years of a prospective, randomized controlled trial with a multifaceted intervention program to decrease exposure to allergens (both inhaled and ingested) and environmental tobacco smoke in the first year of life of infants at high risk for the development of asthma because of their family history. We have previously reported a significant reduction in possible asthma (defined as having, over the past 12 months, at least 2 distinct episodes of cough, each
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Supported by the Canadian Institute of Health Research, the British Columbia Lung Association, and the Manitoba Medical Service Foundation.
Disclosure of potential conflict of interest: A; authors—none disclosed.