Clinical ResearchEarly Repair of Congenital Heart Disease Associated With Increased Rate of Attention Deficit Hyperactivity Disorder Symptoms
Section snippets
Methods
The Izaak Walton Killam (IWK) Children's Heart Centre in Halifax, Nova Scotia is the primary provider of cardiac surgery in the Maritime Provinces of Canada (New Brunswick, Nova Scotia, and Prince Edward Island). There is a regional, prospectively maintained clinical database containing demographic, treatment, and follow-up information on this distinct population. This database was searched to identify eligible subjects. Subjects were included in this study if they were 7-15 years old and had
Results
The IWK Cardiology Database search yielded 170 eligible early cardiac surgery subjects. The response rate from all eligible surgical subjects who underwent early cardiac surgery at the IWK Health centre was 33% (56/170). The total number of early cardiac surgery subjects who responded was 57; however, 1 subject was deemed ineligible based on the information provided in the demographic questionnaire.
The demographic information of early cardiac surgery subjects was compared with that of healthy
Discussion
Though screening tests are, by definition, not diagnostic, these study findings support the significant potential increased risk of ADHD in children undergoing early repair of CHD. This remained true even when controlling for differences in baseline demographic variables. The Global ADHD Working Group found a worldwide ADHD prevalence of 4%-8% in 2005.10 The control population in our study had a comparable prevalence rate (3.33% previously undiagnosed with positive screening scores and 3.33%
Funding Sources
This research was funded by a Category A grant from the IWK Health Centre (CAD$4000).
Disclosures
S.E.S. has received consulting fees/honoraria from Purdue, Abbott, Lilly, Janssen-Ortho, and Shire, but she has no financial relationships relevant to this article to disclose. The other authors have no conflicts of interest to disclose.
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