Clinical InvestigationMemory Dysfunction, Psychomotor Slowing, and Decreased Executive Function Predict Mortality in Patients With Heart Failure and Low Ejection Fraction
Section snippets
Procedures
A prospective study design was used. The data were collected as part of a larger study conducted to evaluate cognitive dysfunction among 414 participants (249 HF patients, 63 healthy participants, and 102 medical participants).23 Data were collected from September 2004 through April 2009. The HF patients were enrolled from 5 outpatient clinic sites in the Midwest. Eligible patients were invited to participate in the study by clinic staff members. The names and contact information of interested
Results
Table 1 presents the demographic and baseline variables for the total sample of 166 patients and of the patients who were alive and those who died over the 12 months. Twelve months after the baseline interviews, 145 patients (87%) were living and 21 patients (13%) had died. A higher percentage of men died compared with women over the 12 months (P = .056). No significant differences were found in age, race, ethnicity, marital status, education, and premorbid intellect between the patients who
Discussion
To our knowledge, this is the first study to report that dysfunction in specific cognitive abilities of working memory, memory (verbal learning and visuospatial recall), psychomotor speed, and executive function are predictors of 12-month all-cause mortality in a general sample of outpatients with chronic HF. More severe HF as indicated by lower LVEF and worse scores on the MMSE, the Digit Span backward, the Hopkins Verbal Learning Test (delayed recall), the Figure Memory recall, the Digit
Acknowledgments
Co-investigators for the study “Cognitive Deficits in Chronic Heart Failure:” David Kareken, PhD, Mary Jane Sauvé, DNSc, Rebecca Sloan, PhD, and Usha Subramanian, MD. Assistance with data collection: Joan Barr, MSN, Clarian Health Partners, Indianapolis, IN; Kari Berron, MSN and Mary Walsh, MD, The Care Group, Indianapolis, IN; Cynthia Adams, PhD, Sara Fickle, MSN, Cynthia Kennedy, MSN, Jeanne Majors, MSN, Sharon Sipos, AD, and Linda Trowbridge, RN, Community Health Network of Indianapolis;
Disclosures
This work was supported by the National Institute of Nursing Research. The authors have no other disclosures related to this study.
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Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
2023, Journal of the Society for Cardiovascular Angiography and InterventionsCognitive Decline and Risk of Dementia in Individuals With Heart Failure: A Systematic Review and Meta-analysis
2022, Journal of Cardiac FailureCitation Excerpt :Only two studies12,29 reported that the HF diagnosis was adjudicated/clinically verified. Ten studies30–32,35,38–41,43,44 included the New York Heart Association functional classification for HF with majority participants falling in either New York Heart Association functional class II or III. Five studies30–32,43,44 explicitly stated that the participants with HF had stable HF.
Randomized Controlled Trial of a Cognitive Intervention to Improve Memory in Heart Failure
2022, Journal of Cardiac FailureHeart failure impairs mood and memory in male rats and down-regulates the expression of numerous genes important for synaptic plasticity in related brain regions
2021, Behavioural Brain ResearchCitation Excerpt :It is now becoming well-accepted that, in addition to neurohumoral activation and the associated systemic cardiac, renal and vascular complications, HF is comorbid with depression, anxiety and memory deficits, both in human patients [6–10] and experimental animal models [11,12]. These mood and cognitive disturbances have serious implications for quality of life and self-care in patients who have HF because hospital readmission and mortality rates are significantly higher in HF patients that have depression and/or cognitive impairments compared to HF patients without these comorbidities [9,13–15]. It is critical to identify the neurobiological mechanisms and substrates that underlie HF-induced mood and cognitive disturbances HF in order to identify treatments that may improve quality of life and decrease mortality in this prevalent disease.
Funded by the National Institute of Nursing Research R01NR008147. Supported by the National Institute of Nursing Research. Institutions where work was done: Indiana University, Indianapolis, Indiana and University of Michigan, Ann Arbor, Michigan.
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