Clinical surgery—internationalThe impact of prophylactic antibiotics on postoperative infection complication in elective laparoscopic cholecystectomy: a prospective randomized study
Section snippets
Patient characteristics
From August 2000 to September 2002, 277 patients suffering from symptomatic gallbladder stones or polyps disease with or without acute cholecystitis who were candidates for elective LC were enrolled in this study consecutively. Patients were divided into 2 groups (A and B) by random numbers of operative schedule. At the time of induction of anesthesia, group A patients (n = 141) received 1 g cefazolin, and group B (control) patients (n = 136) received 10 mL isotonic sodium chloride solution. No
Patient’s characteristics and perioperative data
Fifty male and 91 female patients (mean age 50.3 years) were enrolled in group A, and 55 male and 81 female patients (mean age, 52.9 years) were enrolled in group B. Between group A and B patients, there was no difference in characteristics of patients and surgical outcomes (Table 1).
Postoperative infection complications
Overall rate of SSI was 1.1% for 277 patients. No difference in infection complications was found in either group. The use, or not, of prophylactic antibiotics did not correlate with SSIs (P = .148, Table 1). In
Comments
Our data showed that the overall rate of SSIs after LC was just 1.1% (3 of 277 patients), and it was not related to the use of a single dose of cefazolin (1 g). Only 1 patient in group A had space SSI, and two patients in group B had superficial SSIs (wound infections); all three complications were minor (Table 1). The incidences of SSIs in patients were 0.7% and 1.5% for those receiving prophylactic antibiotics or not, respectively (not statically significant). This was comparable with an SSI
References (30)
- et al.
Infections and bacteriological data after laparoscopic and open gallbladder surgery
J Hosp Infect
(1998) - et al.
How does infected bile affect the postoperative course of patients undergoing laparoscopic cholecystectomy?
Am J Surg
(1996) - et al.
A comparative trial between cefotetan and cephazolin for wound sepsis prophylaxis during elective upper gastrointestinal surgery with an investigation of cefotetan penetration into the obstructed biliary tree
J Hosp Infect
(1986) - et al.
A comparison of cefotetan and cephazolin for prophylaxis against wound infection after elective cholecystectomy
J Hosp Infect
(1985) - et al.
Indications for and outcomes of cholecystectomya comparison of the pre and postlaparoscopic eras
Ann Surg
(1998) - et al.
Risk factors for wound infection after cholecystectomy
J Formos Med Assoc
(2004) - et al.
Infection and antimicrobial use in laparoscopic cholecystectomy
Infect Control Hosp Epidemiol
(1999) - et al.
Mortality and complications associated with laparoscopic cholecystectomy. A meta-analysis
Ann Surg
(1996) - et al.
A prospective randomized study of prophylactic antibiotics in elective laparoscopic cholecystectomy
Surg Endosc
(2003) - et al.
The need for antibiotic prophylaxis in elective laparoscopic cholecystectomya prospective randomized study
Arch Surg
(2000)