Coronary artery diseaseRelation of Severe Deficiency of Vitamin D to Cardiovascular Mortality During Acute Coronary Syndromes
Section snippets
Methods
Consecutive patients with rest onset of typical chest discomfort within the previous 48 hours admitted to the coronary care units of 2 tertiary hospitals in Salvador, Brazil, from August 2007 to December 2011 were evaluated for inclusion in the Registry of Acute Coronary Syndromes (REACS). To include patients with non–ST-segment elevation ACS, ≥1 of the 3 objective criteria had to be present: electrocardiographic changes consisting of transient ST-segment depression (≥0.05 mV) or T-wave
Results
Two hundred six patients were included in the study (mean age 70 ± 13 years, 52% men, 52% African Brazilians), 93% of whom were admitted with non–ST-segment elevation ACS and the remaining with ST-segment elevation myocardial infarctions. Vitamin D concentration had a fairly normal distribution, with a mean of 19.5 ± 8.2 ng/ml, a median of 18.5 ng/ml, and an interquartile range of 13.9 to 23.3 ng/ml (Figure 1). Severe deficiency of vitamin D was present in 10% of the sample (95% confidence
Discussion
The present study demonstrates an independent association between severe deficiency of vitamin D and in-hospital cardiovascular mortality in patients with ACS. To the best of our knowledge, this is the first evidence of such an association in this clinical scenario. In the general population, a significant proportion of patients have serum deficiencies of vitamin D.3, 7 It is known that vitamin D deficiency leads to hyperparathyroidism,8 a condition associated with increased cardiovascular
Disclosures
The authors have no conflicts of interest to disclose.
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Vitamin D and cardiovascular diseases
2024, Advances in Food and Nutrition ResearchCirculating 25-hydroxy-vitamin D and the risk of cardiovascular diseases. Systematic review and meta-analysis of prospective cohort studies
2021, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :There is no previous meta-analysis examining the association between 25(OH)D and recurrent CVD events from a clinical perspective. In line with the current findings, the prospective cohort studies (N = 5 [55–59]) that have been included in our meta-analysis reported that the risk of recurrent CVD events was higher for the deficient (<12 ng/ml) compared to the non-deficient (≥20 ng/ml) 25(OH)D categories. The definition of vitamin D deficiency is quite debatable.
Vitamin D and cardiovascular disease
2018, MaturitasCitation Excerpt :The results of studies overall support an inverse association between vitamin D levels and the risk of incident coronary events. In a sample of 206 patients admitted to hospital for unstable angina, low vitamin D levels were a prognostic factor for in-hospital CV mortality [63]. In the Danish CopD study, increased risk of acute myocardial infarction was observed in patients with both very low (12.5 nmol/L) or very high (125 nmol/L) 25OHVitD levels compared with the reference category of 70 nmol/L (HR 2.1 95% CI: 1.7–2.7; HR 1.6, 95% CI: 1.2–2.0 respectively) [52].
Vitamin D and Calcimimetics in Cardiovascular Disease
2018, Seminars in NephrologyCitation Excerpt :Observational studies have shown a relationship between low vitamin D levels and impaired left ventricular function in a cross-sectional study of patients referred for coronary angiography.47 In addition, vitamin D deficiency is associated with overt coronary heart disease and myocardial infarction, and is prognostic for major postinfarction adverse events including heart failure hospitalizations, recurrent acute myocardial infarction, and death.48,49 Examination of the Health Professionals Follow-up Study in a nested case-control study that included 18,225 men showed that low levels of calcidiol (≤15 nmol/L) were associated with a higher risk of myocardial infarction compared with participants with sufficient levels (≥30 nmol/L) after adjustment for matched variables (relative risk, 2.42; 95% CI, 1.53-3.84).
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