Coronary artery diseaseRelation of Osteoprotegerin to Coronary Calcium and Aortic Plaque (from the Dallas Heart Study)
Section snippets
Study population
The Dallas Heart Study is a population-based, multiethnic, probability sample of 6,101 subjects in Dallas County designed to study cardiovascular disease. Details of the study design and characteristics of the enrolled cohort have been previously described.9 An initial visit for 6,101 participants included a detailed in-home interview for demographic and health-related data, as well as measurements of weight, heart rate, and 5 sequential blood pressure measures. All subjects between the ages of
Results
A total of 3,386 subjects in the Dallas Heart Study underwent measurement of plasma OPG levels. Figure 1 illustrates the distribution of OPG levels in the study population, excluding 16 subjects having plasma OPG >5,000 pg/ml. The median OPG concentration was 1,209 pg/ml. Of the 3,386 subjects in whom plasma OPG levels were measured, 2,730 underwent EBCT scanning for determination of CAC score. Detectable CAC (average CAC score >10 Agatston units on 2 successive scans) was present in 580 (21%)
Discussion
In a large multiethnic population-based sample, plasma OPG levels were associated with the prevalence and extent of CAC and with aortic plaque, specific markers of atherosclerosis. The association between OPG and both measures of atherosclerosis remained statistically significant after adjustment for conventional cardiovascular risk factors.
The results of this study extend previous evidence suggesting an association between elevated circulating OPG levels and vascular disease. In these previous
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The Dallas Heart Study was funded by the Donald W. Reynolds Foundation, Las Vegas, Nevada.