Original articleWide-field Retinal Imaging in the Management of Noninfectious Posterior Uveitis
Section snippets
Methods
In this prospective, observational study of patients with noninfectious posterior uveitis, disease activity and changes in management were assessed based on clinical examination with and without simulated (30- or 60-degree) FA, and then with the addition of wide-field pseudo-color SLO images and FA using the Optos ultra-wide-field SLO (Optos Panoramic 200MA; Optos PLC, Dunfermline, Scotland, United Kingdom). New and established patients in the Divisions of Retina and Ocular Immunology at the
Results
Forty-three patients were enrolled in the index study. All patients received wide-field imaging and angiography following their clinical examination. The Table depicts the percentage of patients who demonstrated disease activity and whether management was changed based on the 4 possible combinations of examination and imaging.
Based on the clinical examination alone, the decision to alter management was made in 6 of 43 patients (14%), and in an additional 1 patient (2%) based on simulated
Discussion
Results from the index study suggest that Ultra wide-field imaging may alter management decisions compared to standard-of-care imaging and clinical examination. Such difference most likely is attributable to peripheral retinal imaging and angiographic findings not easily visualized or identified without wide-field imaging. It is intriguing that though the determination of disease “activity” did not differ with the use of wide-field imaging (when allowing for simulated conventional FA),
John Peter Campbell, MD, MPH, is currently a vitreoretinal fellow at the Casey Eye Institute, Oregon Health Sciences University. He received his doctor of medicine Alpha Omega Alpha from the Johns Hopkins University School of Medicine and master of public health from the Johns Hopkins Bloomberg School of Medicine. Dr Campbell recently completed his residency at the Wilmer Eye Institute at Johns Hopkins University, where he conducted the study with wide-angle imaging. His research interests are
References (14)
- et al.
Ultra-wide-field fluorescein angiography of the ocular fundus
Am J Ophthalmol
(2005) - et al.
Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion
Ophthalmology
(2010) - et al.
The use of ultra wide field fluorescein angiography in evaluation and management of uveitis
Semin Ophthalmol
(2009) - et al.
Ultrawide-angle retinal imaging and retinal detachment
Semin Ophthalmol
(2007) - et al.
Ultra wide-field imaging of choroidal metastasis secondary to primary breast cancer
Semin Ophthalmol
(2009) - et al.
The value of optos panoramic 200MA imaging for the monitoring of large suspicious choroidal lesions
Semin Ophthalmol
(2009) - et al.
Diabetic retinopathy: Comparison of the diagnostic features of ultra-widefield scanning laser ophthalmoscopy optomap with ETDRS 7-field fundus photography
Ophthalmologe
(2011)
Cited by (103)
Quantitative Comparison of Fundus Images by 2 Ultra-Widefield Fundus Cameras
2021, Ophthalmology RetinaCitation Excerpt :Ultra-widefield imaging methods have been shown to reveal significantly more pathologic features compared with conventional fundus photography.14,15 Ultra-widefield FA reveals more pathologic features when compared with 7-standard field imaging for DR.9,16 For uveitis, UWF FA can detect increased pathologic features that otherwise would be missed on conventional angiography.17–19 Currently, commercially available UWF fundus cameras include the Optos P200DTx, Optos P200TE, Optos P200T, and Zeiss Clarus 500 and 700.
Whitcup and Nussenblatt’s Uveitis: Fundamentals and Clinical Practice
2021, Whitcup and Nussenblatt's Uveitis: Fundamentals and Clinical PracticeUltrawide-field fluorescein angiography features in patients with anterior uveitis
2024, Eye (Basingstoke)Wide-Field Fluorescein Angiography in Patients with Idiopathic Acute Anterior Uveitis
2024, Ocular Immunology and InflammationUltrawide-Field Fluorescein Angiography Features in Patients with Anterior Uveitis
2023, Research Square
John Peter Campbell, MD, MPH, is currently a vitreoretinal fellow at the Casey Eye Institute, Oregon Health Sciences University. He received his doctor of medicine Alpha Omega Alpha from the Johns Hopkins University School of Medicine and master of public health from the Johns Hopkins Bloomberg School of Medicine. Dr Campbell recently completed his residency at the Wilmer Eye Institute at Johns Hopkins University, where he conducted the study with wide-angle imaging. His research interests are in international ophthalmology, diabetic retinopathy, and blindness prevention. At the completion of his vitreoretinal fellowship, Dr Campbell will return to Wilmer to serve as Chief Resident and Assistant Chief of Service.
Henry Alexander Leder, MD, is currently an assistant professor of ophthalmology at the Albert Einstein College of medicine. He received his bachelor of science in Physics from Yale University in 1997 and doctor of medicine from the University of Connecticut in 2002. In 2006 he completed his residency at the Louisiana State University/ Alton Ochsner Clinic Foundation program. After his residency, he went on to complete fellowship in ocular immunology and uveitis at the Wilmer Eye Institute, Johns Hopkins University followed by a medical retina fellowship at the Duke University Eye Center, and a vitreo-retinal surgery fellowship at Wilmer, where he conducted the study with wide-angle imaging. In 2008 he was appointed the first Stephen J. Ryan Assistant Chief of Service at Wilmer. At that time, he also worked for the Food and Drug administration as an ORISE consultant. Dr Leder's research interests are posterior uveitis and retinal diseases with special focus on retinal imaging, and novel medical and surgical therapies.