Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes

doi:10.1016/S1472-6483(10)60471-3

Reproductive BioMedicine Online

Volume 16, Issue 5, 2008, Pages 608-610

https://doi.org/10.1016/S1472-6483(10)60471-3 Get rights and content

Abstract

Cryopreservation of oocytes by vitrification is a promising new technique for assisted human reproduction. Any new technical development must be accompanied with data concerning obstetric and perinatal outcome. This study analysed the obstetric and perinatal outcomes in 165 pregnancies and 200 infants conceived following oocyte vitrification cycles in three assisted reproduction centres. The results indicate that the mean birth weight and the incidence of congenital anomalies are comparable to that of spontaneous conceptions in fertile women or infertile women undergoing in-vitro fertilization treatment. These preliminary findings may provide reassuring evidence that pregnancies and infants conceived following oocyte vitrification are not associated with increased risk of adverse obstetric and perinatal outcomes.

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Are children born from vitrified-warmed oocytes physically or mentally different from naturally conceived children?
Intracytoplasmic sperm injection (ICSI) of vitrified-warmed oocytes was performed for 282 patients (307 cycles) from August 2000 to March 2020. Long-term follow-up of children born from vitrified-warmed oocytes was performed via a questionnaire that was sent to the parents at regular intervals from 3 to 72 months after the child's birth. Questionnaires were sent 11 times from birth to the age of 6 years. The development of motor function and mental status was evaluated as the primary outcome, based on the reported data. Subsequently, patients were divided into four groups by age at oocyte retrieval (20–29, 30–34, 35–39, and 40 years or older). Clinical outcomes were calculated as a secondary outcome.
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This is the first follow-up report of children born from vitrified-warmed oocytes followed by ICSI. The data suggested that the responses from the study participants on the mental and physical development of children were comparable to the data reported by the government, although more responses from patients should be collected to allow further study.
A follow-up survey on the reproductive intentions and experiences of women undergoing planned oocyte cryopreservation
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Citation Excerpt :
Recent studies show a promising neonatal outcome for pregnancies arising from vitrified oocytes. For example, analysis of the obstetric and perinatal outcomes of infants conceived by vitrified oocytes showed that the mean birthweight and the incidence of congenital anomalies were comparable to that of spontaneous conceptions (Chian et al., 2008). Another study found no significant differences in terms of complications in fetal outcome, although there were higher rates of maternal complications such as pre-eclampsia, gestational hypertension, placental abruption, Caesarean delivery and preterm birth in women over the age of 40 years (Jahromi and Husseini, 2008).
What are the current reproductive attitudes and experiences of women who have previously undergone planned oocyte cryopreservation (OoC)?
Retrospective questionnaire-based cohort study involving women who had previously undergone planned OoC between January 2009 and September 2016 at a single centre. Eligible women were contacted via e-mail and invited to complete an anonymous standardized questionnaire that had been developed to evaluate their current relationship status and reproductive situation, their attitudes towards planned OoC and their future reproductive intentions.
Of 460 women who had completed at least one OoC cycle, questionnaires were obtained from 138 women. After a mean (± SD) follow-up of 4.5 ± 2.4 years, two-thirds of respondents (65%) anticipated using their oocytes at some point in the future. The respondents reported an overwhelmingly positive attitude towards planned OoC, with 98% indicating they would recommend this intervention to others. Overall, 83% of respondents were single at the time they requested OoC but only 44% were single at the time they completed the survey. While 43/62 (69%) of women became pregnant after undergoing OoC, the majority 30/43 (70%) of these pregnancies were achieved without using their vitrified oocytes. Finally, 13/28 (46%) who used their cryopreserved oocytes stated that they had achieved a live birth.
The majority of women who undergo OoC do not regret their experience and many have found a partner in subsequent years. Twenty-one per cent of respondents who attempted to conceive after OoC had a live birth using their cryopreserved oocytes.
Fertility preservation and preimplantation genetic assessment for women with breast cancer
2020, Cryobiology
Breast cancer is the most common cancer diagnosed among reproductive aged women, and its treatment can compromise future fertility. Options for fertility preservation include oocyte or embryo cryopreservation after ovarian stimulation (OS), which are the most established choices and are applicable for adult women with cancer. Ovarian tissue freezing may also be appropriate, as it offers potentially the least delay. The recognisation of the role of BRCA1 and BRCA2 mutations in some women has led to the involvement of preimplantation genetic diagnosis (PGD), recently renamed preimplantation genetic testing for monogenic disorder (PGT-M), whereby embryos are created by IVF and cell(s) are removed and genetically analyzed for specific disease-related mutations. PGT-M offers a valid option for women wishing to avoid transmission of the predisposition for hereditary breast cancer to their offspring. The aim of this paper is to provide an overview of the factors that influence fertility preservation in newly diagnosed breast cancer patients, and to illustrate the option of PGT-M to enable conception of an unaffected child.
Dynactin pathway-related gene expression is altered by aging, but not by vitrification
2019, Reproductive Toxicology
The storage of surplus oocytes by cryopreservation (OC) is a widely used tool in assisted reproductive technology, but there is a great debate about the effects of cryopreservation on oocyte competence. It is known that OC may affect meiotic spindles but remains unclear if OC may increase the risk of aneuploidy. The aim of this study was to test the effects of OC and women aging on the expression of cytokinesis-related genes playing an important role in the segregation of chromosomes (DCTN1, DCTN2, DCTN3, DCTN6 and PLK1). Results highlighted that OC do not modify the expression of the selected genes, whereas women aging modulate the expression of all transcripts, confirming that aging is the crucial factor affecting meiosis and aneuploidy risk. A new role for Dynactin and PLK1 was shed in light, providing information on the ageing process in the oocyte which may be associated to reduced fertility.

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CommentaryObstetric and perinatal outcome in 200 infants conceived from vitrified oocytes

Abstract

Reproductive BioMedicine Online

Reproductive BioMedicine Online

Reproductive BioMedicine Online

Fertility and Sterility

Lancet

Fertility and Sterility

Reproductive BioMedicine Online

Reproductive BioMedicine Online

Reproductive BioMedicine Online

Fertility and Sterility

Fertility and Sterility

Reproductive BioMedicine Online

Fertility and Sterility

Reproductive BioMedicine Online

Reproductive BioMedicine Online

Fertility and Sterility

Fertility and Sterility

Reproductive BioMedicine Online

American Journal of Obstetrics and Gynecology

Commentary
Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes