Elsevier

The Lancet

Volume 353, Issue 9170, 19 June 1999, Page 2125
The Lancet

Research Letters
Serial magnetic resonance imaging of cerebral atrophy in preclinical Alzheimer's disease

https://doi.org/10.1016/S0140-6736(99)00496-1Get rights and content

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    One of the most readily available methods comes from morphometric estimates obtained using structural MRI. Structural MRI studies examining N in AD have frequently focused on hippocampal volume (Jack et al., 1992; Storandt et al., 2009; van Maurik et al., 2017), global atrophy (Fagan et al., 2009; Fox et al., 1999; Schott et al., 2010; van Maurik et al., 2017), and an “AD signature” consisting of a composite of thickness or volumetric estimates derived from regions impacted early during the course of AD (Dickerson et al., 2011; Dickerson and Wolk, 2012; Schwarz et al., 2016). A previous study, which compared multiple thickness- and volumetric-based methods for obtaining an AD signature, found that thickness-based AD signatures from FreeSurfer and Statistical Parametric Mapping (SPM) + DiReCT (the cortical thickness algorithm from Advanced Normalization Tools (ANTs)) had the strongest correlations with Braak neurofibrillary tangle stage at autopsy (Schwarz et al., 2016).

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