Mucormycosis in systemic lupus erythematosus
Section snippets
Methods
A patient with SLE who presented with headache and multiple cranial nerve palsies in the setting of a nephritic flare is reported. She was initially treated for active neuropsychiatric lupus with heavy immunosuppression. However, her condition deteriorated rapidly and a final diagnosis of extensive rhinocerebral mucormycosis was made at autopsy. Culture of a nasal swab specimen yielded Rhizopus species.
A Medline search for articles published between 1970 and 2002 regarding mucormycosis in SLE
Case report
A 36-year-old Chinese woman was admitted in June 2000 because of fever, arthritis, and generalized anasarca caused by nephrotic syndrome. SLE was diagnosed in 1990 when she presented with photosensitive facial rash, polyarthritis, and diffuse proliferative nephritis, for which high-dose prednisone and intravenous pulse cyclophosphamide were administered. Her nephritis remitted after cyclophosphamide treatment, and she remained stable throughout these years while maintained on low-dose
Mycology
Mucormycosis is a rare opportunistic infection caused by fungi of the order Mucorales (class Zygomycetes) (26). Most infections are caused by Mucor, Rhizopus, Absidia, and Rhizomucor species from the family Mucoraceae, and rarely by Cunninghamella from the family Cunninghamellaceae and other species. Apophysomyces elegans, a newly recognized genus and species classified in the family Mucoraceae, has been recently reported to cause mucormycosis 27, 28, 29. The fungi are ubiquitous in the
References (62)
Infection in systemic lupus erythematosus
Rheum Dis Clin North Am
(1998)- et al.
Nocardiosis in systemic lupus erythematosus
Semin Arthritis Rheum
(1997) - et al.
Invasive aspergillosis in systemic lupus erythematosus
Semin Arthritis Rheum
(1995) - et al.
Aspergillosis in systemic lupus erythematosus
Semin Arthritis Rheum
(1996) - et al.
Cutaneous zygomycosis (mucormycosis) complicating endotracheal intubationDiagnosis and successful treatment
Chest
(1998) - et al.
Gastrointestinal mucormycosis mimicking ischemic colitis in a patient with systemic lupus erythematosus
Am J Gastroenterol
(1998) - et al.
Pulmonary mucormycosis presenting as an endobronchial lesion
Chest
(1994) - et al.
Fatal invasive gastric mucormycosis occurring with emphysematous gastritiscase report and literature review
Am J Gastroenterol
(1999) Mucormycosis of the nose and paranasal sinuses
Otolaryngol Clin North Am
(2000)- et al.
Adjunctive hyperbaric oxygen in the treatment of bilateral cerebro-rhino-orbital mucormycosis
Am J Ophthalmol
(1992)
Locally invasive cutaneous Apophysomyces elegans infection acquired from snapdragon patch test
Mayo Clin Proc
Rhino-orbital and rhino-orbito-cerebral mucormycosis
Otolaryngol Head Neck Surg
Rhinocerebral and systemic mucormycosis. Clinical experience with 36 cases
J Neurol Sci
Pulmonary mucormycosisresults of medical and surgical therapy
Ann Thorac Surg
Functional asplenia in systemic lupus erythematosus
Semin Arthritis Rheum
Mortality and causes of death in systemic lupus erythematosus
Curr Opin Rheumatol
A prospective study of survival and prognostic indicators of systemic lupus erythematosus in a southern Chinese population
Rheumatology (Oxford)
Incidence studies of systemic lupus erythematosus in Southern SwedenIncreasing age, decreasing frequency of renal manifestations and good prognosis
J Rheumatol
Systemic lupus erythematosus in North American IndiansA population based study
J Rheumatol
A multicenter study of outcome in systemic lupus erythematosus. II. Causes of death
Arthritis Rheum
Morbidity and mortality in systemic lupus erythematosus during a 5-year period. A multicenter prospective study of 1,000 patients. European Working Party on Systemic Lupus Erythematosus
Medicine (Baltimore)
Outcome of a cohort of 300 patients with systemic lupus erythematosus attending a dedicated clinic for over two decades
Ann Rheum Dis
Systemic lupus erythematosus and infectionA controlled and prospective study including an epidemiological group
Q J Med
Fatal infections in systemic lupus erythematosusthe role of opportunistic organisms
Medicine (Baltimore)
Mortality in systemic lupus erythematosusThe bimodal pattern revisited
Q J Med
Incidence of infection in systemic lupus erythematosus
Arthritis Rheum
Cryptococcal meningitis presenting concurrently with systemic lupus erythematosus
Clin Exp Rheumatol
Fatal coccidioidomycosis in collagen vascular diseases
J Rheumatol
Rhizopus, Rhizomucor, Absidia, and other agents of systemic and subcutaneous zygomycoses
Disseminated zygomycosis masquerading as cerebral lupus erythematosus
Am J Clin Pathol
Disseminated zygomycosis associated with systemic lupus erythematosus
J Rheumatol
Cited by (0)
- 1
Chi Chiu Mok, MD, MRCP: Consultant in Rheumatology, Department of Medicine, Tuen Mun Hospital, Hong Kong
- 2
Tak Lun Que, FRCPA, FRCPath: Senior Consultant, Department of Microbiology, Tuen Mun Hospital, Hong Kong
- 3
Edmund Yik Kong Tsui, MBBS, FRCR: Consultant, Department of Radiology, Tuen Mun Hospital, Hong Kong
- 4
Wing Yin Lam, MBBS, FRCPath, FIAC: Senior Consultant, Department of Pathology, Tuen Mun Hospital, Hong Kong, China.