Intracellular calcium signaling systems in the pathophysiology of affective disorders
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Essential elements in depression and anxiety. Part i
2014, Pharmacological ReportsCitation Excerpt :Disturbances in calcium metabolism have been reported in different types of affect disorders. A study showed that intracellular calcium concentrations are increased in platelets following application of 10 μM 5-HT to platelets taken from patients with bipolar disorder and depression but not control, suggesting that patients with these mood disorders have an increased calcium signalling system via 5-HT 2A receptors [127]. A study by Bowden and colleagues [128] investigated extracellular and intracellular calcium in patients with unipolar, bipolar or manic patients.
Desipramine-induced Ca<sup>2+</sup> movement and cytotoxicity in PC3 human prostate cancer cells
2007, Toxicology in VitroAnimal models of bipolar disorder
2007, Neuroscience and Biobehavioral ReviewsBlockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test
2006, NeuropharmacologyCitation Excerpt :Other reports showed that dihydropyridine channel blockers displayed antidepressant-like activity in mice (Cohen et al., 1997; Biala, 1998) as well as some effectiveness in the treatment of patients with affective disorders (Dubovsky, 1993; Wisner et al., 2002). Acute application of antidepressant drugs inhibited intracellular calcium signalling and Ca2+-related signalling in cultured neuronal cells and glioma cells (Yamawaki et al., 1998). Taken together, these results suggest the presence of an altered intracellular calcium homeostasis in depressed patients that is neither receptor- nor cell-specific, indicating that a component in the calcium pathway other than the receptor itself may be abnormal.