Elsevier

Life Sciences

Volume 62, Issues 17–18, 27 March 1998, Pages 1665-1670
Life Sciences

Intracellular calcium signaling systems in the pathophysiology of affective disorders

https://doi.org/10.1016/S0024-3205(98)00125-8Get rights and content

Abstract

In this paper, we show the importance of intracellular calcium (Ca2+) signaling systems in the pathophysiology of mood disorders based on our recent work. Patients with affective disorders appear to have an enhanced intracellular Ca2+ rise in response to serotonin. We have observed effects of antidepressant drugs on intracellular Ca2+ sinaling in rat cultured neuronal cells and glioma cells, and found that acute application of several classes of antidepressant drugs inhibited intracellular Ca2+ signaling and Ca2+-related signaling. It is important to investigate the role of intracellular Ca2+ signaling system for an understanding of the pathophysiology of affective disorders.

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