Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial☆
Section snippets
Methods
Between June 1988 and July 1991, 454 patients with optic neuritis were enrolled into the ONTT and completed the baseline testing (one enrolled patient withdrew before completing the baseline testing, and two patients were found to have a compressive optic nerve lesion rather than optic neuritis). Patients provided written informed consent for each follow-up phase. After the conclusion of the treatment trial in 1992, 410 patients consented to continued follow-up, and in 1997, 387 patients again
Results
An examination was completed for 319 (82%) of the 387 patients who consented to continue in follow-up beyond 1997. The time from entry into the ONTT until the examination ranged from 9.9 to 13.7 years. For 272 patients (85%), the examination was completed at one of the original ONTT clinical centers. The remaining 47 patients (15%) completed the examination with a nonstudy ophthalmologist, because returning to an ONTT clinical center was not feasible.
Among the 454 patients in the original ONTT
Discussion
Continued follow-up of the cohort of patients who were enrolled into the ONTT has provided a unique opportunity to assess the long-term course of vision after an episode of acute optic neuritis. We found that in most patients, once visual acuity stabilized after the initial episode of optic neuritis (as determined from the acuity measurement 1 year after the episode), it remained remarkably stable for more than 10 years. After 10 years, 69% of patients had acuity of 20/20 or better in each eye,
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Cited by (0)
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This study was supported by a Cooperative Agreement (U10 EY09435) from the National Eye Institute, National Institutes of Health.
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The writing committee, investigators, and coordinators who participated in the study are listed in the Appendix.