Elsevier

Annals of Epidemiology

Volume 1, Issue 3, February 1991, Pages 263-276
Annals of Epidemiology

The cardiovascular health study: Design and rationale

https://doi.org/10.1016/1047-2797(91)90005-WGet rights and content

Abstract

The Cardiovascular Health Study (CHS) is a population-based, longitudinal study of coronary heart disease and stroke in adults aged 65 years and older. The main objective of the study is to identify factors related to the onset and course of coronary heart disease and stroke. CHS is designed to determine the importance of conventional cardiovascular disease (CVD) risk factors in older adults, and to identify new risk factors in this age group, especially those that may be protective and modifiable. The study design called for enrollment of 1250 men and women in each of four communities: Forsyth County, North Carolina; Sacramento County, California; Washington County, Maryland; and Pittsburgh, Pennsylvania. Eligible participants were sampled from Medicare eligibility lists in each area. Extensive physical and laboratory evaluations were performed at baseline to identify the presence and severity of CVD risk factors such as hypertension, hypercholesterolemia and glucose intolerance; subclinical disease such as carotid artery atherosclerosis, left ventricular enlargement, and transient ischemia; and clinically overt CVD. These examinations in CHS permit evaluation of CVD risk factors in older adults, particularly in groups previously under-represented in epidemiologic studies, such as women and the very old. The first of two examination cycles began in June 1989. A second comprehensive examination will be repeated three years later. Periodic interim contacts are scheduled to ascertain and verify the incidence of CVD events, the frequency of recurrent events, and the sequellae of CVD.

References (39)

  • H.L. Taylor et al.

    A questionnaire for the assessment of leisure time physical activities

    J Chronic Dis.

    (1978)
  • M.F. Folstein et al.

    Mini-Mental State: A practical method for grading the cognitive state of patients for the clinician

    J Psychiat Res.

    (1975)
  • W.B. Kannel et al.

    Primary risk factors for coronary heart disease in the elderly: The Framingham Study

  • G. Rose et al.

    Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study

    Br Med J

    (1986)
  • C.C. Seltzer

    Smoking and coronary heart disease in the elderly

    Am J Med Sci

    (1975)
  • R.D. Langer et al.

    Paradoxical survival of elderly men with high blood pressure

    Br Med J.

    (1989)
  • K. Mattila et al.

    Blood pressure and five year survival in the very old

    Br Med J.

    (1988)
  • M. Feinleib et al.

    Coronary heart disease in the elderly: The magnitude of the problem in the United States

  • G. Spencer

    U.S. Bureau of the Census, Projections of the population of the United States by age, sex and race: 1983–2020

  • N.K. Wenger et al.

    Coronary heart disease in the elderly: Review of current knowledge and research recommendations

  • J.B. MacDonald

    Presentation of acute myocardial infarction in the elderly-a review

    Age Ageing.

    (1984)
  • G. Gerstenblith et al.

    Disorders of the heart

  • CHS Collaborative Research Group. CHS Manuals of Operation: No. 1, protocol; no. 2, Field Center Procedures; no. 3,...
  • I. McDowell et al.

    Measuring health: A guide to rating scales and questionnaires

  • C.A. Heitsmann et al.

    Assessment of methods for measuring social support

    Health Psychology

    (1988)
  • J.E. Lubben

    Assessing social networks among elderly populations

    J Health Promo Maint

    (1988)
  • J.A. Wells

    Chronic life situations and life change events

  • J. Orme et al.

    Factorial and indiscriminate validity of the center for epidemiological studies depression (CES-D) scale

    J.Clin Psychol

    (1986)
  • R.S. Paffenbarger et al.

    Physical activity as an index of heart attack risk in college alumni

    Am J Epidemiol

    (1978)
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