Original contributionSoluble interleukin 6 receptor in biological fluids from human origin
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Proteolytic control of Interleukin-11 and Interleukin-6 biology
2017, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :Whether the strength or duration of intracellular signaling induced by soluble or membrane-bound receptors differs is not clear. Soluble (s)IL-11R is found in the serum of healthy humans in a range from 20 pg/ml to 4 ng/ml [94], while sIL-6R is found in concentrations between 30–70 ng/ml under normal conditions [95,96]. Serum levels of sIL-6R have been shown to be elevated under pathological conditions, albeit the increase is rather small compared to the IL-6 levels [97,98].
Neurotrophic factors and their inhibitors in chronic pain treatment
2017, Neurobiology of DiseaseCitation Excerpt :Yasukawa et al. (1990) showed that the sensitivity of cells expressing both IL6R and gp130 to IL6 was further increased in the presence of the soluble IL6 receptor (sIL6R) (Yasukawa et al., 1990). Additionally, a naturally occurring secreted version of the IL6R has been reported in human serum and urine (Novick et al., 1989; Frieling et al., 1994). Healthy individuals contain around 80 ng/ml of sIL6R in the serum, and this is increased under certain disease states such as HIV and multiple myeloma (Narazaki et al., 1993; Honda et al., 1992).
The IL-6/sIL-6R treatment of a malignant melanoma cell line enhances susceptibility to TNF-α-induced apoptosis
2007, Biochemical and Biophysical Research CommunicationsNovel role of IL-6/SIL-6R signaling in the expression of inducible nitric oxide synthase (iNOS) in murine B16, metastatic melanoma clone F10.9, cells
2007, Free Radical Biology and Medicine