Do antidepressants cause, promote, or inhibit cancers?
References (43)
- et al.
Circumvention of pleiotropic drug resistance in subcutaneous tumours in vivo with verapamil and clomipramine
Eur J Cancer
(1991) The effect of a serotonin uptake inhibitor on the secretion of prolactin in the rat
Life Sci
(1975)- et al.
Stimulation of in vivo tumor growth and phorbol ester-induced inflammation by N,N-diethyl-2-(-4-(phenylmethyl)- phenoxy) ethanamine HC1, a potent ligand for intracellular histamine receptors
Biochem Biophys Res Comm
(1991) - et al.
A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes
Biochem Biophys Res Comm
(1984) - et al.
Inhibition and metabolite complexation of rat hepatic microsomal cytochrome P450 by tricyclic antidepressants
Biochem Pharmacol
(1992) - et al.
Metabolism of propranolol by rat liver microsomes and its inhibition by phenothiazine and tricyclic antidepressant drugs
Biochem Pharmacol
(1971) - et al.
Chlorpromazine and related antipsychotic tricyclic compounds competitively inhibit the interaction between tumorpromoting phorbol esters and their specific receptors
Cancer Lett
(1982) - et al.
Effects of tricycle antidepressant drugs on energy-linked reactions in mitochondria
Biochem Pharmacol
(1986) - et al.
Chronic variable stress facilitates tumoral growth: reversal by imipramine administration
Life Sci
(1992) - et al.
Influence of desmethylimipramine on natural killer cell activity
Psychiatry Res
(1986)
The effect of antidepressants on immune function in mice
Biol Psychiatry
Depression and the cancer patient
J Clin Psychiatry
Prevalence of selected mental disorders
Pros and cons of fluoxetine for the depressed cancer patient
Oncology
Stimulation of malignant growth in rodents by antidepressant drugs at clinically relevant doses
Cancer Res
Neonatal antidepressant treatment promotes DMBA- induced mammary tumor growth
Carcinogenicity studies of fluoxetine hydrochloride in rats and mice
Cancer Res
Preclinical toxicology of bupropion: an overview
J Clin Psychiatry
Influence of inhibitors of serotonin uptake on intestinal epithelium and colorectal carcinomas
Br J Cancer
Potentiation of chemotherapeutic effect of vincristine in vincristine resistant tumor bearing mice by calmodulin inhibitor clomipramine
J Pharm Dyn
Cytostatic activity of commonly used tricyclic antidepressants
Oncology
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Drug repositioning: Using psychotropic drugs for the treatment of glioma
2022, Cancer LettersCitation Excerpt :In the following sections, we discuss the accumulated evidence supporting the therapeutic application of antidepressant drugs to the treatment of glioma. Imipramine is a tricyclic antidepressant (TCA) that is effective for the treatment of severe depression and acts by inhibiting the reuptake of serotonin and norepinephrine [48]. Recent studies have shown that imipramine treatment decreased cancer cell invasion and survival.
Risk of depressive symptoms before and after the first hospitalisation for cancer: Evidence from a 16-year cohort study in the Czech Republic
2020, Journal of Affective DisordersBeneficial effect of fluoxetine on anti-tumor progression on hepatocellular carcinoma and non-small cell lung cancer bearing animal model
2020, Biomedicine and PharmacotherapyProstate cancer and antidepressants: A nationwide population-based nested case-control study
2018, Journal of Affective DisordersCitation Excerpt :Brandes et al. reported increased DNA synthesis in malignant cells stimulated by TCAs in rodents (Brandes et al., 1992). Steingart et al. suggested increased cancer risk due to suppression of immune function (Steingart and Cotterchio, 1995). Harlow et al. described elevations in levels of gonadotropins affected by changes in dopamine or norepinephrine in response to antidepressants (Harlow et al., 1998).
Inhibition of P-glycoprotein and Glutathione S-transferase-pi mediated resistance by fluoxetine in MCF-7/ADM cells
2013, Biomedicine and PharmacotherapyCitation Excerpt :FLX, as a new SSRI, has been used to treat depression effectively in clinical for a decade, as well as in cancer patients with depression. But there is a dispute on the relationship between FLX and cancer [16–18]. On one hand, clinically doses of FLX was reported to accelerate the growth of mammary tumors in rodents, and on the other, however, late studies revealed that FLX inhibits proliferation of several cancer cell lines, such as colon cancer, breast cancer, astrocytoma, lung cancer, neuroblastoma, and medulloblastoma, rhabdomyosarcoma cell lines.