ArticleFunctional changes of the peripheral nervous system with aging in the mouse
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2020, Experimental NeurologyCitation Excerpt :Thus, the generalizability of findings from rodent studies of CIPN would be improved by the inclusion of groups of older animals. There are well known age-related changes in the function and structure of the peripheral nerves (Verdú et al., 1996; Ceballos et al., 1999; Canta et al., 2016). Moreover, the response to insults and toxic events tends to decline and vary with age.
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2016, Neurobiology of AgingInhibition of the neuronal NFκB pathway attenuates bortezomib-induced neuropathy in a mouse model
2016, NeuroToxicologyCitation Excerpt :The compound muscle action potential (CMAP) was recorded from the plantar interosseus muscle with microneedle electrodes. Similarly, the sensory compound nerve action potential (SNAP) was recorded by electrodes placed at the fourth toe near the digital nerves (Verdú and Navarro, 1996) A rotarod apparatus for small rodents (LIAP) was used to assess general sensory-motor function.
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2016, Neurobiology of AgingChanges in the connective tissue sheath of Wistar rat nerve with aging
2014, Annals of AnatomyCitation Excerpt :Changes in peripheral nerves have been reported both in relation to pathology and in non-pathological aging (King, 2001; Platt et al., 2003; Yasuda et al., 2003). The literature describes some morphological and functional age-dependent changes in peripheral nerves, such as abnormalities in myelination (Verdú et al., 1996), axonal loss (Sharma and Thomas, 1975) and alterations in connective tissue and vascularization (Ceballos et al., 1999), as well as changes in target organs, such as reduction of muscle mass (Aniansson et al., 1981) and loss of sensory receptors (Schimirgk and Ruttinger, 1980). The regenerative ability of peripheral nerves can also be affected by aging (Ceballos et al., 1999).