A ubiquitous intracellular parasite: The cellular biology of Toxoplasma gondii
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Cited by (62)
Development of multistage recombinant protein vaccine formulations against toxoplasmosis using a new chitosan and porin based adjuvant system
2022, International Journal of PharmaceuticsCitation Excerpt :Toxoplasmosis is a zoonotic infection of warm-blooded animals, including humans, caused by obligate intracellular protozoan parasite Toxoplasma gondii (T. gondii) (Halonen & Weiss, 2013; Kasper & Boothroyd, 1993; Tenter, Heckeroth, & Weiss, 2000). The infection is transmitted in various ways such as consuming contaminated water, vegetables and fruits, raw or undercooked meat, contact with cat feces, organ transplantation, blood transfusion, etc. (Kasper & Boothroyd, 1993; Smith, 1995). The acute infection leads to mild symptoms (fever, weakness, headache) in people with a healthy immune system, while in people with suppressed or insufficient immune systems, it mainly affects the central nervous system and may cause severe disorders such as hepatitis, pericarditis, myocarditis and lymphadenitis.
Toxoplasma and Eimeria co-opt the host cFos expression for intracellular development in mammalian cells
2021, Computational and Structural Biotechnology JournalCitation Excerpt :To investigate the gene expression in parasitized YAMC cells, we infected them with tachyzoites of T. gondii or with sporozoites of E. falciformis, both of which invaded with similar efficiency (40%), as deduced by immunostaining 4 h post-infection (Fig. 1A). Unlike Toxoplasma tachyzoites, which divide to form the identical progeny [19], Eimeria sporozoites can only develop into trophozoite and schizont stages, and culture is usually aborted 24 h post-infection. We chose 4 h and 16 h for our transcriptomic analysis to discern the infection-linked rewiring of gene expression in host cells.
Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability
2018, Bioorganic and Medicinal Chemistry LettersIsolation and characterization of Heat Shock Protein 100-Batu1 from Toxoplasma gondii RH strain
2015, Experimental ParasitologyCitation Excerpt :Humans can be infected through several ways; consumption of uncooked meat, consumption of water and food which are contaminated with cat and dog feces, and blood transfusion and organ transplantation. Further, the parasite may infect fetus by placental pathway from mother (Smith, 1995). In humans, T. gondii replicates via an asexual cycle and both tachyzoites and bradyzoites forms of the parasite exist in the body.
Identification of differentially expressed proteins in sulfadiazine resistant and sensitive strains of Toxoplasma gondii using difference-gel electrophoresis (DIGE)
2013, International Journal for Parasitology: Drugs and Drug ResistanceCitation Excerpt :Toxofilin is an actin binding protein which is associated with PP2C and secreted into host cells during invasion (Jan et al., 2007), although the main role of toxofilin remains unclear (Lodoen et al., 2010). T. gondii dense granule proteins participate in the modification of the parasitophorous vacuole (PV), which provides an unusual and highly specialized environment for parasite growth and development (Smith, 1995). Previous studies have shown that GRA2, a dense granule protein of T. gondii plays a role in protein trafficking to the dense granules, secretion into the vacuole, association with vacuolar membranes, induction of the membranous nanotubular network formation and organization of the parasites within the vacuole (Travier et al., 2008) and in this study the abundance of 28 kDa antigen (GRA2) was higher in the resistant strain TgH 32006 compared to the sensitive strain.
Proteases as regulators of pathogenesis: Examples from the Apicomplexa
2012, Biochimica et Biophysica Acta - Proteins and ProteomicsCitation Excerpt :This process of invasion occurs within a very short time frame because the extracellular forms cannot survive for long periods of time outside host cells. Invasion proceeds following an initial contact by the polar zoite, which reorients such that its apical end contacts the host cell membrane [16,17]. A tight junction that results from the interaction of multiple receptor proteins forms between the apposed parasite and host membranes, and this junction moves from the apical to the posterior end of the zoite.