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Headache attributed to hypothyroidism

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Abstract

Clinical and subclinical hypothyroidisms are common conditions in the population. Clinic-based studies suggest that hypothyroidism may be an exacerbating factor for some primary headaches. Furthermore, hypothyroidism may be a risk factor for incident new daily persistent headache. This article reviews the classification of the headaches attributed to hypothyroidism according to the second edition of the International Classification of Headache Disorders. We also review the prevalence, etiology, and principles of treatment of hypothyroidism. Because hypothyroidism is a treatable cause of secondary headaches, doctors should be aware of this relationship.

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References and Recommended Reading

  1. Lipton RB, Diamond S, Reed M, et al.: Migraine diagnosis and treatment: results from the American Migraine Study II. Headache 2001, 41:638–645.

    Article  PubMed  CAS  Google Scholar 

  2. Lipton RB, Stewart WF, Diamond S, et al.: Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 2001, 41:646–657.

    Article  PubMed  CAS  Google Scholar 

  3. Headache Classification Subcommittee of the International Headache Society. Classification of Headache Disorders, 2nd ed. Cephalalgia 2004, 24(Suppl 1):1–150.

    Google Scholar 

  4. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias, and facial pain. Cephalalgia 1988, 8(Suppl 7):1–96.

    Google Scholar 

  5. Moreau T, Manceau E, Giroud-Baleydier F, et al.: Headache in hypothyroidism. Prevalence and outcome under thyroid hormone therapy. Cephalalgia 1998, 18:687–689.

    Article  PubMed  CAS  Google Scholar 

  6. Spierings EGL: Daily migraine with visual aura associated with an occipital arteriovenous malformation. Headache 2001, 41:193–197.

    Article  PubMed  CAS  Google Scholar 

  7. Bigal ME, Sheftell FD, Rapoport AM, et al.: Chronic daily headache: identification of factors associated with induction and transformation. Headache 2002, 42:575–581.

    Article  PubMed  Google Scholar 

  8. Bigal ME, Sheftell FD, Rapoport AM, et al.: MMPI personality profiles in patients with primary chronic daily headache. A case-control study. Neurol Sci 2003, 24:103–110.

    Article  PubMed  CAS  Google Scholar 

  9. Hollowell JG, Staehling NW, Flanders WD, et al.: Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002, 87:489–499.

    Article  PubMed  CAS  Google Scholar 

  10. Canaris GJ, Manowitz NR, Mayor G, Ridgeway EC: The Colorado thyroid disease prevalence study. Arch Intern Med 2000, 160:526–534.

    Article  PubMed  CAS  Google Scholar 

  11. Surks MI, Ortiz E, Daniels GH, et al.: Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA 2004, 29:228–238.

    Article  Google Scholar 

  12. Lindeman RD, Schade DS, La Rue A, et al.: Subclinical hypothyroidism in a biethnic, urban community. J Am Geriatr Soc 1999, 47:703–709.

    PubMed  CAS  Google Scholar 

  13. Helfand M, Redfern CC: Clinical guideline, part 2. Screening for thyroid disease: an update. American College of Physicians. Ann Intern Med 1998, 129:144–158.

    PubMed  CAS  Google Scholar 

  14. Mason RL, Hunt HM, Hurxthal L: Blood cholesterol values in hyperthyroidism and hypothyroidism. N Engl J Med 1930, 203:1273–1278.

    Article  CAS  Google Scholar 

  15. Hak AE, Pols HA, Visser TJ, et al.: Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med 2000, 132:270–278.

    PubMed  CAS  Google Scholar 

  16. Helfand M: Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med 2004, 140:128–141.

    PubMed  Google Scholar 

  17. Garber JR, Hennessey JV, Lieberman JA, et al.: Managing the challenges of hypothyroidism. J Fam Pract 2006, 56(Suppl):S1–S8.

    Google Scholar 

  18. Robin NI: The Clinical Handbook of Endocrinology and Metabolic Disease. Pearl River, NY: Parthenon Publishing Group; 1996:85–88.

    Google Scholar 

  19. Scher AI, Stewart WF, Ricci JA, Lipton RB: Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 2003, 106:81–89.

    Article  PubMed  CAS  Google Scholar 

  20. Bigal ME, Lipton RB: Obesity is a risk factor for transformed migraine but not for chronic tension-type headache. Neurology 2006, 67:252–257.

    Article  PubMed  Google Scholar 

  21. Pears J, Jung RT, Gunn A: Long-term weight changes in treated hyperthyroid and hypothyroid patients. Scott Med J 1990, 35:180–182.

    PubMed  CAS  Google Scholar 

  22. Jameson JL, Weetman AP: Hypothyroidism. In Harrison’s Principles of Internal Medicine, edn 13. New York: McGraw-Hill; 2005:2108–2109.

    Google Scholar 

  23. Vanderpump MP, Tunbridge WM, French JM, et al.: The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol 1995, 43:55–68.

    CAS  Google Scholar 

  24. Clyde PW, Harari AE, Getka EJ, Shakir KM: Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. JAMA 2003, 290:2952–2958.

    Article  PubMed  CAS  Google Scholar 

  25. Bruno AN, Pochmann D, Ricachenevsky FK, et al.: Nociceptive response and adenine nucleotide hydrolysis in synaptosomes isolated from spinal cord of hypothyroid rats. Neurochem Res 2005, 30:1155–1161.

    Article  PubMed  CAS  Google Scholar 

  26. Giffin NJ, Kowacs F, Libri V, et al.: Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects. Cephalalgia 2003, 23:287–292.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Marcelo E. Bigal MD, PhD.

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Tepper, D.E., Tepper, S.J., Sheftell, F.D. et al. Headache attributed to hypothyroidism. Current Science Inc 11, 304–309 (2007). https://doi.org/10.1007/s11916-007-0208-2

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