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Gestational Diabetes: Implications for Cardiovascular Health

  • Diabetes and Pregnancy (CJ Homko, Section Editor)
  • Published:
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Abstract

Gestational diabetes mellitus (GDM) is a pregnancy complication that is becoming more prevalent with recent population trends in obesity and advancing maternal age. A diagnosis of GDM not only increases risk for maternal and fetal complications during pregnancy, but also significantly increases a woman’s risk of both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in the postpartum. Even women with milder forms of abnormal glucose homeostasis during pregnancy, specifically gestational impaired glucose tolerance, are at increased risk, justifying the recent recommendation to tighten the diagnostic criteria for GDM, thus implicating many more women. Risk factors that increase risk for future CVD among women with a history of GDM include postpartum progression to T2DM; metabolic syndrome; obesity; hypertension; and altered levels of circulating inflammatory markers, specifically, adiponectin, C-reactive protein, and tumor necrosis factor-α. Medical therapies such as metformin that prevent progression to T2DM may prove to be our primary defense against earlier CVD among women with GDM.

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Abbreviations

DPP:

Diabetes Prevention Program

HAPO:

Hyperglycemia and Adverse Pregnancy Outcomes

IADPSG:

International Association of Diabetes in Pregnancy Study Group

KEEP:

Kidney Early Evaluation Program

PIPOD:

Pioglitazone in Prevention of Diabetes

TRIPOD:

Troglitazone in Prevention of Diabetes.

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Authors and Affiliations

  1. Department of Endocrinology, Washington Hospital Center, 110 Irving Street, NW, Suite 2A-72, Washington, DC, 20010, USA

    Shannon D. Sullivan

  2. Medstar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattesville, MD, 20782, USA

    Jason G. Umans & Robert Ratner

  3. Georgetown-Howard Universities Center for Clinical and Translational Science, Washington, DC, USA

    Jason G. Umans & Robert Ratner

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  1. Shannon D. Sullivan
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  2. Jason G. Umans
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  3. Robert Ratner
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Correspondence to Robert Ratner.

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Sullivan, S.D., Umans, J.G. & Ratner, R. Gestational Diabetes: Implications for Cardiovascular Health. Curr Diab Rep 12, 43–52 (2012). https://doi.org/10.1007/s11892-011-0238-3

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