Abstract
Following deep vein thrombosis (DVT), one of every two patients will develop postthrombotic syndrome (PTS), which causes remarkable consequences on the socioeconomic level. Residual thrombosis is an important predictor of PTS, and severe early symptoms, old age, obesity, improper anticoagulation, recurrent thrombosis and varicose veins are major risk factors. Diagnosis of PTS is mainly based on the clinical findings for patients with a history of DVT, while in those without it, instrumental diagnosis might help in detecting a previous DVT. Prompt administration of adequate compression elastic stockings (ECS) in patients with symptomatic DVT reduces the frequency of PTS by half. Usually, the management of an established PTS is demanding, and often discouraging. However, when carefully supervised and instructed to wear proper ECS, more than 50% of patients either remain quiescent or improve during long-term follow-up.
Similar content being viewed by others
References
Kahn SR, Ginsberg JS (2004) Relationship between deep venous thrombosis and the postthrombotic syndrome. Arch Intern Med 164:17–26
Kahn SR, M’Lan CE, Lamping DL, Kurz X, Bérard A, Abenhaim L (2004) The influence of venous thromboembolism on quality of life and severity of chronic venous disease. J Thromb Haemost 2:2146–2151
Prandoni P, Lensing AWA, Cogo A et al (1996) The long-term clinical course of acute deep venous thrombosis. Ann Intern Med 125:1–7
Prandoni P, Villalta S, Bagatella P et al (1997) The clinical course of deep-vein thrombosis: prospective long-term follow-up of 528 symptomatic patients. Haematologica 82:423–428
Prandoni P, Lensing AWA, Prins MH, Bagatella P, Scudeller A, Girolami A (1999) Which is the outcome of the postthrombotic syndrome? Thromb Haemost 82:1196–1197
Kahn SR, Kearon C, Julian JA et al (2005) Predictors of the postthrombotic syndrome during long-term treatment of proximal deep vein thrombosis. J Thromb Haemost 3:718–723
Kahn SR, Shrier I, Julian JA et al (2008) Determinants and time course of the postthrombotic syndrome after acute deep venous thrombosis. Ann Intern Med 149:698–707
Roumen-Klappe EM, den Heijer M, Janssen MCH, van der Vleuten C, Thien T, Wollersheim H (2005) The postthrombotic syndrome: incidence and prognostic value of non-invasive venous examinations in a six-year follow-up study. Thromb Haemost 94:825–830
Schulman S, Lindmarker P, Holmstrom M et al (2005) Postthrombotic syndrome, recurrence, and death 10 years after the first episode of venous thromboembolism treated with warfarin for 6 weeks or 6 months. J Thromb Haemost 4:734–742
Aschwanden M, Jeanneret C, Koller MT, Thalhammer C, Bucher HC, Jaeger KA (2008) Effect of prolonged treatment with compression stockings to prevent postthrombotic sequelae: a randomized controlled trial. J Vasc Surg 47:1015–1021
Tick LW, Kramer MH, Rosendaal FR, Faber WR, Doggen CJM (2008) Risk factors for postthrombotic syndrome in patients with a first deep venous thrombosis. Thromb Haemost 6:2075–2081
Carter CJ (1990) Incidence of post-phlebitic syndrome after streptokinase therapy for deep vein thrombosis. Am J Med 89:697–698
Markel A, Manzo RA, Bergelin RO, Strandness DE (1992) Valvular reflux after deep vein thrombosis: incidence and time of occurrence. J Vasc Surg 15:377–384
Johnson BF, Manzo RA, Bergelin RO, Strandness DE (1995) Relationship between changes in the deep venous system and the development of the postthrombotic syndrome after an acute episode of lower limb deep vein thrombosis: a one- to six-year follow-up. J Vasc Surg 21:307–313
Franzeck UK, Schalch I, Bollinger A (1997) On the relationship between changes in the deep veins evaluated by Duplex sonography and the postthrombotic syndrome 12 years after deep vein thrombosis. Thromb Haemost 77:1109–1112
Haenen JH, Janssen MC, Wollersheim H et al (2002) The development of postthrombotic syndrome in relationship to venous reflux and calf muscle pump dysfunction at 2 years after the onset of deep venous thrombosis. J Vasc Surg 35:1184–1189
Singh H, Masuda EM (2005) Comparing short-term outcomes of femoral-popliteal and iliofemoral deep venous thrombosis: early lysis and development of reflux. Ann Vasc Surg 19:74–79
González-Fajardo JA, Martin-Pedrosa M, Castrodeza J, Tamames S, Vaquero-Puerta C (2008) Effect of the anticoagulant therapy in the incidence of postthrombotic syndrome and recurrent thromboembolism: comparative study of enoxaparin versus coumarin. J Vasc Surg 48:953–959
Coleridge Smith PD, Thomas P, Scurr JH, Dormandy JA (1988) Causes of venous ulceration: a new hypothesis. Br Med J 296:1726–1727
Shami SK, Shields DA, Scurr JH, Smith PD (1992) Leg ulceration in venous disease. Postgrad Med J 68:779–785
Roumen-Klappe E, der Heijer M, van Uum S, van der Ven-Jongekrijg J, van der Graaf F, Wollersheim H (2002) Inflammatory response in the acute phase of deep vein thrombosis. J Vasc Surg 35:701–706
Raju S (1983) Venous insufficiency of the lower limbs and stasis ulceration. Ann Surg 197:688–697
Immelman EJ, Jeffrey PC (1984) The postphlebitic syndrome: pathophysiology, prevention and management. Clin Chest Med 5:537–550
Scott TE, LaMorte WW, Gorin DR, Menzoian JO (1995) Risk factors for chronic venous insufficiency: a dual case–control study. J Vasc Surg 22:622–628
Browse NL, Clemenson G, Lea TM (1980) Is the postphlebitic leg always postphlebitic? Relation between phlebographic appearances of deep-vein thrombosis and late sequelae. Br J Hosp Med 281:1167–1170
Bettmann MA, Paulin S (1977) Leg phlebography: the incidence, nature, and modification of undesirable side effects. Radiology 122:101–104
Barnes RW (1985) Doppler ultrasonic diagnosis of venous disease. In: Bernstein EF (ed) Noninvasive diagnostic techniques in vascular disease, 3rd edn. Mosby Co, St. Louis, pp 724–729
Villalta S, Bagatella P, Piccioli A, Lensing AWA, Prins MH, Prandoni P (1994) Assessment of validity and reproducibility of a clinical scale for the postthrombotic syndrome. Haemostasis 24:158a
Prandoni P, Lensing AWA, Prins MH et al (2004) Below-knee elastic compression stockings to prevent the postthrombotic syndrome: a randomized, controlled trial. Ann Intern Med 141:249–256
Kahn SR, Partsch H, Vedantham S, Prandoni P, Kearon C (2009) Definition of postthrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization. J Thromb Haemost Jan 19. [Epub ahead of print]
Kahn SR (2009) Measurement properties of the Villalta scale to define and classify the severity of the postthrombotic syndrome. J Thromb Haemost Mar 6. [Epub ahead of print]
Kolbach DN, Sandbrink MWC, Hamulyak K, Neumann HAM, Prins MH (2003) Non-pharmaceutical measures for prevention of postthrombotic syndrome. The Cochrane database of systematic reviews issue 4. art. no.: CD004174. doi:10.1002/14651858.CD004174
Kahn SR, Hirsch A, Shrier I (2002) Effect of postthrombotic syndrome on health related quality of life after deep venous thrombosis. Arch Intern Med 162:1144–1148
Rodger MA, Kahn SR, Le Gal G et al (2008) Inter-observer reliability of measures to assess the postthrombotic syndrome [Letter]. Thromb Haemost 100:164–166
Kolbach DN, Neumann HA, Prins MH (2005) Definition of the postthrombotic syndrome, differences between existing classifications. Eur J Vasc Endovasc Surg 30:404–414
Porter JM, Moneta GL (1995) Reporting standards in venous disease: an update: International Consensus Committee on Chronic Venous Disease. J Vasc Surg 21:635–645
Villalta S, Prandoni P, Cogo A et al (1995) The utility of non-invasive tests for detection of previous proximal-vein thrombosis. Thromb Haemost 73:592–596
van Dongen CJ, Prandoni P, Frulla M, Marchiori A, Prins MH, Hutten BA (2005) Relation between quality of anticoagulant treatment and the development of the postthrombotic syndrome. J Thromb Haemost 3:939–942
Stain M, Schonauer V, Minar E et al (2005) The postthrombotic syndrome: risk factors and impact on the course of thrombotic disease. J Thromb Haemost 3:2671–2676
Ageno W, Piantanida E, Dentali F et al (2003) Body mass index is associated with the development of the postthrombotic syndrome. Thromb Haemost 89:305–309
Wille-Jorgensen P, Jorgensen LN, Crawford M (2005) Asymptomatic postoperative deep vein thrombosis and the development of postthrombotic syndrome: a systematic review and meta-analysis. Thromb Haemost 93:236–241
Lindner DJ, Edwards JM, Phinney ES, Taylor LM, Porter JM (1986) Long-term hemodynamic and clinical sequelae of lower extremity deep vein thrombosis. J Vasc Surg 4:436–442
Monreal M, Martorell A, Callejas J et al (1993) Venographic assessment of deep vein thrombosis and risk of developing post-thrombotic syndrome: a prospective study. J Intern Med 233:233–238
Philbrick JT, Becker DM (1988) Calf deep venous thrombosis: a wolf in sheep’s clothing? Arch Intern Med 148:2131–2138
Schulman S, Granqvist S, Juhlin-Dannfelt A, Lockner D (1986) Long-term sequelae of calf vein thrombosis treated with heparin or low-dose streptokinase. Acta Medica Scand 219:349–357
McLafferty RB, Moneta GL, Passman MA et al (1998) Late clinical and hemodynamic sequelae of isolated calf vein thrombosis. J Vasc Surg 27:50–56
Ziegler S, Schillinger M, Maca TH, Minar E (2001) Postthrombotic syndrome after primary event of deep venous thrombosis 10–20 years ago. Thromb Res 101:23–33
Piovella F, Crippa L, Barone M et al (2002) Normalization rates of compression ultrasonography in patients with a first episode of deep vein thrombosis of the lower limbs: association with recurrence and new thrombosis. Haematologica 87:515–522
Prandoni P, Lensing AWA, Prins MH et al (2002) Residual venous thrombosis as a predictive factor of recurrent venous thromboembolism. Ann Intern Med 137:955–960
Prandoni P, Prins MH, Lensing AWA et al, AESOPUS Investigators (2009) Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial. Ann Intern Med 150:577–585
Prandoni P, Frulla M, Sartor D, Concolato A, Girolami A (2005) Vein abnormalities and the postthrombotic syndrome. J Thromb Haemost 3:401–402
Cushman M, Folsom AR, Wang L et al (2003) Fibrin fragment D-dimer and the risk of future venous thrombosis. Blood 101:1243–1248
Cosmi B, Legnani C, Cini M, Guazzaloca G, Palareti G (2005) D-dimer levels in combination with residual venous obstruction and the risk of recurrence after anticoagulation withdrawal for a first idiopathic deep vein thrombosis. Thromb Haemost 94:969–974
Bauer K (2005) Hypercoagulable states. Hematology 10(Suppl 1):39
Palareti G, Cosmi B (2004) Predicting the risk of recurrence of venous thromboembolism. Curr Opin Hematol 11:192–197
Shbaklo H, Holcroft CA, Kahn SR (2009) Levels of inflammatory markers and the development of the post-thrombotic syndrome. Thromb Haemost 101:505–512
Kahn SR, Shbaklo H, Shapiro S et al (2007) Effectiveness of compression stockings to prevent the postthrombotic syndrome (the SOX Trial and Bio-SOX biomarker substudy): a randomized controlled trial. BMC Cardiovasc Disord 7:21
Bergqvist D, Jendteg S, Johansen L, Persson U, Ödegaard K (1997) Cost of long term complications of deep venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden. Ann Intern Med 126:454–457
Goldhaber SZ, Buring JE, Lipnick RJ, Hennekens CH (1984) Pooled analyses of randomized trials of streptokinase and heparin in phlebographically documented acute deep venous thrombosis. Am J Med 76:393–397
Wells P, Forster AJ (2001) Thrombolysis in deep vein thrombosis: is there still an indication? Thromb Haemost 86:499–508
Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ (2008) Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians evidence-based clinical practice guidelines (8th edn). Chest 133(Suppl. 6):454S–545S
Park YJ, Choi JY, Min SK et al (2008) Restoration of patency in iliofemoral deep vein thrombosis with catheter-directed thrombolysis does not always prevent postthrombotic damage. Eur J Vasc Endovasc Surg 36:725–730
Enden T, Sandvik L, Klow NE et al (2007) Catheter-directed venous thrombolysis in acute iliofemoral vein thrombosis-the CaVenT study: rationale and design of a multicenter, randomized, controlled, clinical trial. Am Heart J 154:808–814
Kahn SR, Elman E, Rodger MA, Wells PS (2003) Use of elastic compression stockings after deep venous thrombosis: a comparison of practices and perceptions of thrombosis physicians and patients. J Thromb Haemost 1:500–506
Brandijes DPM, Büller HR, Heijboer H, Huisman MV, de Rijk M, Jagt H (1997) Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet 349:759–762
Kakkos SK, Daskalopoulou SS, Daskalopoulos ME, Nicolaides AN, Geroulakos G (2006) Review on the value of graduated elastic compression stockings after deep vein thrombosis. Thromb Haemost 96:441–445
Sajid MS, Tai NR, Goli G, Morris RW, Baker DM, Hamilton G (2006) Knee versus thigh length graduated compression stockings for prevention of deep venous thrombosis: a systematic review. Eur J Vasc Endovasc Surg 32:730–736
Nelson EA, Harper DR, Prescott RJ, Gibson B, Brown D, Ruckley CV (2006) Prevention of recurrence of venous ulceration: randomized controlled trial of class 2 and class 3 elastic compression. J Vasc Surg 44:803–808
Partsch H, Kaulich M, Mayer W (2004) Immediate mobilisation in acute vein thrombosis reduces postthrombotic syndrome. Int Angiol 3:206–212
Hafner J, Bounameaux H, Burg G, Brunner U (1996) Management of venous leg ulcers. Vasa 25:161–167
Evers EJ, Wuppermann T (1999) Effect of different compression therapies on the reflux in deep veins with a postthrombotic syndrome. Vasa 28:19–23
Milne AA, Ruckley CV (1994) The clinical course of patients following extensive deep venous thrombosis. Eur J Vasc Surg 8:56–59
Erickson CA, Lanza DJ, Karp DL et al (1995) Healing of venous ulcers in an ambulatory care program: the roles of chronic venous insufficiency and patients compliance. J Vasc Surg 22:629–636
Kahn SR, Azoulay L, Hirsch A, Haber M, Strulovitch C, Shrier I (2003) Effect of graduated elastic compression stockings on leg symptoms and signs during exercise in patients with deep venous thrombosis: a randomized cross-over trial. J Thromb Haemost 1:494–499
Ginsberg JS, Magier D, Mackinnon B, Gent M, Hirsh J (1999) Intermittent compression units for severe post-phlebitic syndrome: a randomised crossover study. Can Med Assoc J 160:1303–1306
O’Donnell MJ, McRae S, Kahn SR et al (2008) Evaluation of a venous-return assist device to treat severe postthrombotic syndrome (VENOPTS): a randomized controlled trial. Thromb Haemost 99:463–464
Colgan MP, Dormandy JA, Jones PW, Schraibman IG, Shanik G, Young RA (1990) Oxpentifylline treatment of venous ulcers of the leg. Br Med J 300:972–975
Layton AM, Ibbotson SH, Davies JA, Goodfield MJ (1994) Randomized trial of oral aspirin for chronic venous leg ulcer. Lancet 344:164–165
Rudofsky G (1989) Intravenous prostaglandin E1 in the treatment of venous ulcers—a double-blind, placebo-controlled trial. Vasa 28(Suppl):39–43
Salim AS (1992) Role of sulphydril-containing agents in the management of venous (varicose) ulceration: a new approach. Clin Exp Derm 17:427–432
Salim AS (1991) The role of oxygen-derived free radicals in the management of venous (varicose) ulceration: a new approach. World J Surg 15:264–269
Coccheri S, Scandotto G, Agnelli G, Aloisi D, Palazzini E, Zamboni V (2002) Randomised, double blind, multicentre, placebo controlled study of sulodexide in the treatment of venous leg ulcers. Thromb Haemost 87:947–952
Burnand K, Clemenson G, Morland M, Jarret PE, Browse NL (1980) Venous lipodermatosclerosis: treatment by fibrinolytic enhancement and elastic compression. Br Med J 280:7–11
de Jongste AB, Jonker JJC, Huisman MV, ten Cate JW, Azar AJ (1989) A double blind three center clinical trial on the short-term efficacy of 0-(β-hydroxyethyl)-rutosides in patients with postthrombotic syndrome. Thromb Haemost 62:826–829
Frulla M, Marchiori A, Sartor D et al (2005) Elastic stockings, hydroxyethylrutosides or both for the treatment of postthrombotic syndrome. Thromb Haemost 93:183–185
Baste JC, Midy F (1994) Surgery for postthrombotic syndrome of the lower limbs. Rev Prat 44:781–785
Gloviczki P, Bergan JJ, Rhodes JM, Canton LG, Harmsen S, Ilstrup DM (1999) Mid-term results of endoscopic perforator vein interruption for chronic venous insufficiency: lessons learned from the North American subfascial endoscopic perforator surgery registry. The North American Study Group. J Vasc Surg 29:489–502
Perrin M, Hiltbrand B, Bayon JM (1999) Results of valvuloplasty in patients presenting deep venous insufficiency and recurring ulceration. Ann Vasc Surg 13:524–532
Conflict of interest statement
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Pesavento, R., Villalta, S. & Prandoni, P. The postthrombotic syndrome. Intern Emerg Med 5, 185–192 (2010). https://doi.org/10.1007/s11739-009-0336-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11739-009-0336-2