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Neurologic Changes during Critical Illness: Brain Imaging Findings and Neurobehavioral Outcomes

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Abstract

Encephalopathy and other neurologic morbidities are common in critical illness, sepsis, and prolonged mechanical ventilation. We assessed structural changes on brain imaging and neuropsychological outcomes in critically ill patients who developed neurological changes during their intensive care unit (ICU) stay. Patients who underwent brain imaging for neurological changes were included in the study. Medical, neuroradiological, and outcome data were obtained from patient medical records. Sixty-four patients underwent brain imaging for neurological changes. Forty-one (64%) patients had abnormalities on brain imaging. There were no differences for age, hospital length of stay, ICU length of stay, duration of mechanical ventilation or APACHE II scores for patients with normal compared to abnormal brain imaging. Cognitive impairments occurred in 48% of survivors and 6% developed psychiatric disorders. Our study demonstrates that abnormalities on brain imaging are common in critically ill patients. We also confirm previous findings that survivors of critical illness have cognitive impairments post-ICU discharge. This study further illustrates the adverse effects of critical illness on the brain and highlights the need for additional research in this emerging area.

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Acknowledgements

We would like to thank Colin Key, PhD for consultation on the statistical analysis.

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Authors and Affiliations

  1. Department of Medicine, Pulmonary and Critical Care Division, LDS Hospital, Salt Lake City, UT, USA

    Mary R. Suchyta, Al Jephson & Ramona O. Hopkins

  2. Department of Medicine, Pulmonary and Critical Care Division, Intermountain Medical Center, Murray, UT, USA

    Mary R. Suchyta, Al Jephson & Ramona O. Hopkins

  3. Psychology Department and Neuroscience Center, Brigham Young University, Provo, UT, USA

    Ramona O. Hopkins

  4. Critical Care Medicine, Intermountain Medical Center, 5121 South Cottonwood Street, Murray, UT, 84107, USA

    Ramona O. Hopkins

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  1. Mary R. Suchyta
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  2. Al Jephson
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Correspondence to Ramona O. Hopkins.

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Suchyta, M.R., Jephson, A. & Hopkins, R.O. Neurologic Changes during Critical Illness: Brain Imaging Findings and Neurobehavioral Outcomes. Brain Imaging and Behavior 4, 22–34 (2010). https://doi.org/10.1007/s11682-009-9082-3

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