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Geographic Ancestry and Cause-specific Mortality in a National Population

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Abstract

There are marked differentials in mortality risks across regions in Finland. No exhaustive explanation to this variation has been provided, however. The aim of this paper is to analyse how geographic ancestry, as proxied by persons’ birth region and population group, interrelates with cause-specific mortality risks. Focusing on people aged between their mid-thirties and late-forties, we use longitudinal population register data that offer opportunities to account for variables that represent both persons’ social background and their own social status at young adult age. Results of Cox proportional hazard models say that these variables have substantial effects on mortality of different causes, but only a marginal impact on the variation in death rates by birth region and population group. The geographic mortality pattern is found to be specifically prominent for causes of death that are fairly unrelated to persons’ lifestyles. Our findings suggest that genetic predisposal as expressed in terms of geographic ancestry might play a relevant role in understanding mortality variation within the population of Finland.

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References

  • Bamshad, M. (2005). Genetic influences on health. Journal of the American Medical Association, 294, 937–946.

    Article  Google Scholar 

  • Bamshad, M. (2006). Race and genetic influences on health – reply. Journal of the American Medical Association, 295, 385.

    Article  Google Scholar 

  • Bartley, M. (1994). Unemployment and ill health: Understanding the relationship. Journal of Epidemiology and Community Health, 48, 333–337.

    Article  Google Scholar 

  • Blomgren, J., Martikainen, P., Mäkelä, P., & Valkonen, T. (2004). The effects of regional characteristics on alcohol-related mortality – a register-based multilevel analysis of 1.1 million men. Social Science & Medicine, 58, 2523–2535.

    Article  Google Scholar 

  • Cubbin, C., LeClere, F. B., & Smith, G. S. (2000). Socioeconomic status and injury mortality: Individual and neighbourhood determinants. Journal of Epidemiology and Community Health, 54, 517–524.

    Article  Google Scholar 

  • Edwards, A. W. F. (2003). Human genetic diversity: Lewontin’s fallacy. BioEssays, 25, 798–801.

    Article  Google Scholar 

  • Eley, T. C., & Plomin, R. (1997). Genetic analyses of emotionality. Current Opinion in Neurobiology, 7, 279–284.

    Article  Google Scholar 

  • Eriksson, A. W. (1973). Genetic polymorphisms in Finno-Ugrian populations. Israel Journal of Medical Sciences, 9, 1156–1170.

    Google Scholar 

  • Eriksson, A. W., Partanen, K., Frants, R. R., Pronk, J. C., & Kostense, P. J. (1986). ABH secretion polymorphism in Icelanders, Åland Islanders, Finns, Finnish Lapps, Komi and Greenland Eskimos: A review and new data. Annals of Human Biology, 13, 273–285.

    Article  Google Scholar 

  • Galea, S., Freudenberg, N., & Vlahov, D. (2005). Cities and population health. Social Science & Medicine, 60, 1017–1033.

    Article  Google Scholar 

  • Helgason, A., Yngvadóttir, B., Hrafnkelsson, B., Gulcher, J., & Stefánsson, K. (2005). An Icelandic example of the impact of population structure on association studies. Nature Genetics, 37, 90–95.

    Google Scholar 

  • Hesselbrock, V., Begleiter, H., Porjesz, B., O’Connor, S., & Bauer, L. (2001). P300 event-related potential amplitude as an endophenotype of alcoholism – evidence from the collaborative study on the genetics of alcoholism. Journal of Biomedical Science, 8, 77–82.

    Google Scholar 

  • Hu, Y., & Goldman, N. (1990). Mortality differentials by marital status: An international comparison. Demography, 27, 233–250.

    Article  Google Scholar 

  • Jackson, F. L. C. (2004). Human genetic variation and health: New assessment approaches based on ethnogenetic layering. British Medical Bulletin, 69, 215–235.

    Article  Google Scholar 

  • Kajanoja, P. (1972). A contribution to the physical anthropology of the Finns. Annales Academiae Scientiarum Fennicae, Series A, V Medica, 153.

  • Kauppila, R. (2003). Sudden and unexpected natural and violent deaths in females in comparison to deaths in males. A medico-legal autopsy study in the province of Southern Finland during the years 1985, 1992, and 1999. Doctoral Dissertation, University of Helsinki, Department of Forensic Medicine.

  • Korkiasaari, J., & Söderling, I. (1994). Muuttoliike. In S. Koskinen, T. Martelin, I.-L. Notkola, V. Notkola, & K. Pitkänen (Eds.), Suomen Väestö (pp. 226–264). Hämeenlinna: Gaudeamus.

    Google Scholar 

  • Koskinen, S. (1994). Origin of regional differences in mortality from ischaemic heart disease in Finland. Doctoral Dissertation. Research Reports, No. 41. National Research and Development Centre for Welfare and Health, Jyväskylä.

  • Koskinen, S., & Martelin, T. (1994). Kuolleisuus. In S. Koskinen, T. Martelin, I.-L. Notkola, V. Notkola, & K. Pitkänen (Eds.), Suomen Väestö (pp. 150–225). Hämeenlinna: Gaudeamus.

    Google Scholar 

  • Koskinen, S., & Martelin, T. (2003). Why is mortality low among the Swedish-speaking minority in Finland? Yearbook of Population Research in Finland, 39, 15–32.

    Google Scholar 

  • Lagercrantz, H. (2007). Gene–environment interaction is now hype. Acta Paediatrica, 96, 1253.

    Article  Google Scholar 

  • Langford, I. H., & Bentham, G. (1996). Regional variations in mortality rates in England and Wales: An analysis using multi-level modelling. Social Science & Medicine, 42, 897–908.

    Article  Google Scholar 

  • Lunetta, P., Penttilä, A., & Sarna, S. (2001). The role of alcohol in accident and violent deaths in Finland. Alcoholism: Clinical & Experimental Research, 25, 1654–1661.

    Article  Google Scholar 

  • Luy, M. (2004). Mortality differences between Western and Eastern Germany before and after reunification. A macro and micro level analysis of developments and responsible factors. Genus, 60, 99–141.

    Google Scholar 

  • Martelin, T. (1994). Differential mortality at older ages. Doctoral Dissertation, Publications of the Finnish Demographic Society, No. 16, Helsinki.

  • Martikainen, P. T., & Valkonen, T. (1996). Excess mortality of unemployed men and women during a period of rapidly increasing unemployment. Lancet, 348, 909–912.

    Article  Google Scholar 

  • McGue, M. (1999). The behavioral genetics of alcoholism. Current Directions in Psychological Science, 8, 109–115.

    Article  Google Scholar 

  • Norio, R. (2003). Finnish disease heritage. Human Genetics, 112, 441–526.

    Google Scholar 

  • Parra, F. C., Amado, R. C., Lambertucci, J. R., Rocha, J., Antunes, C. M., & Pena, S. D. J. (2003). Color and genomic ancestry in Brazilians. Proceedings of the National Academy of Sciences of the United States of America, 100, 177–182.

    Article  Google Scholar 

  • Pensola, T. H. (2003). From past to present: Effect of lifecourse on mortality, and social class differences in mortality in middle adulthood. Doctoral Dissertation. Yearbook of Population Research in Finland, 39, Supplement.

  • Pitkänen, K., Koskinen, S., & Martelin, T. (2000). Kuolleisuuden alue-erot ja niiden historia. Duodecim, 116, 1697–1710.

    Google Scholar 

  • Rosenberg, N. A., Mahajan, S., Ramachandran, S., Zhao, C., Pritchard, J. K., & Feldman, M. W. (2005). Clines, clusters, and the effect of study design on the inference of human population structure. PloS Genetics, 1, e70.

    Article  Google Scholar 

  • Risch, N., Burchard, E., Ziv, E., & Tang, H. (2002). Categorisation of humans in biomedical research: Genes, race and disease. Genome Biology, 3, 1–12.

    Article  Google Scholar 

  • Saarela, J. (2006). Wealth in two ethnic groups: The role of internal migration background. Finnish Yearbook of Population Research, 42, 43–64.

    Google Scholar 

  • Saarela, J., & Finnäs, F. (2005a). Mortality inequality in two native population groups. Population Studies, 59, 313–320.

    Article  Google Scholar 

  • Saarela, J., & Finnäs, F. (2005b). Geographical extraction and the Finnish-Swedish health differential in Finland. Yearbook of Population Research in Finland, 41, 61–73.

    Google Scholar 

  • Saarela, J., & Finnäs, F. (2006). Regional mortality variation in Finland: A study of two population groups. Genus, 62, 169–211.

    Google Scholar 

  • Saarela, J., & Finnäs, F. (2008). Cause-specific mortality at young ages: Lessons from Finland. Health & Place, 14, 265–274.

    Article  Google Scholar 

  • Sahi, T. (1974). Lactose malabsorption in Finnish speaking and Swedish speaking populations in Finland. Scandinavian Journal of Gastroenterology, 9, 303–308.

    Google Scholar 

  • Sauli, H. (1979). Ammatti ja kuolleisuus 1971–75. Research Reports, No. 54. Statistics Finland, Helsinki.

  • Simpura, J. (1990). Hur dricker finlandssvensken? Finska Läkarsällskapets Handlingar, 150, 168–170.

    Google Scholar 

  • Statistics Finland. (2007a). Causes of death. http://pxweb2.stat.fi/database/PX-Web%20StatFin/Terveys/Kuolemansyyt/Kuolemansyyt.asp. Accessed 4 April 2007.

  • Statistics Finland. (2007b). Population. http://pxweb2.stat.fi/database/V%E4est%F6/V%E4est%F6rakenne/V%E4est%F6rakenne.asp. Accessed 4 April 2007.

  • Statistics Finland. (2007c). Causes of death and population: Swedish speakers (Complementary data, not available online). Accessed 4 April 2007.

  • Statistics Finland. (2007d). Data description. Väestölaskentojen pitkittäistiedosto 1970–1995. http://www.stat.fi/meta/rekisteriselosteet/rekisteriseloste_vaestolaskenta70-95.html. Accessed 4 April 2007.

  • Statistics Finland. (2007e). Victims of violence by perpetrator, age and sex 1998–2005. http://pxweb2.stat.fi/database/StatFin/ter/ksyyt/ksyyt_fi.asp. Accessed 4 April 2007.

  • Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000). Genetic epidemiology of major depression: Review and meta-analysis. American Journal of Psychiatry, 157, 1552–1562.

    Article  Google Scholar 

  • Valkonen, T. (1987). Male mortality from ischaemic heart disease in Finland: Relation to region of birth and region of residence. European Journal of Population, 3, 61–83.

    Article  Google Scholar 

  • Valkonen, T., & Kauppinen, T. M. (2001). Miesten kuolleisuuden alue-erot ja sosiaalinen segregaatio pääkupunkiseudulla. Kvartti, (1), 7–21.

  • Valkonen, T., Martelin, T., Rimpelä, A., Notkola, V., & Savela, S. (1992). Sosioekonomiset kuolleisuuserot 1981–90. SVT Väestö, No. 8. Helsinki.

  • Virtaranta-Knowles, K., Sistonen, P., & Nevanlinna, H. R. (1991). A population genetic study in Finland: Comparisons of the Finnish- and Swedish-speaking populations. Human Heredity, 41, 248–264.

    Article  Google Scholar 

  • Workman, P. L., Mielke, J. H., & Nevanlinna, H. R. (1976). The genetic structure of Finland. American Journal of Physical Anthropology, 44, 341–367.

    Article  Google Scholar 

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Acknowledgements

Comments from two anonymous referees and participants at the 18th Nordic Conference in Social Medicine and Public Health are gratefully acknowledged.

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Correspondence to Jan Saarela.

Appendix

Appendix

Table A1 95% confidence intervals for the parameters in Table 3
Table A2 95% confidence intervals for the parameters in Table 4
Table A3 95% confidence intervals for the parameters in Table 5

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Saarela, J., Finnäs, F. Geographic Ancestry and Cause-specific Mortality in a National Population. Popul Res Policy Rev 28, 169–194 (2009). https://doi.org/10.1007/s11113-008-9079-4

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