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IL-12Rβ1 Deficiency and Disseminated Mycobacterium tilburgii Disease

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Abstract

Mycobacterium tilburgii rarely causes disseminated disease. We describe a case of M. tilburgii infection in an otherwise healthy 33-year-old woman, who was found to carry bi-allelic mutations of the gene encoding the β1 chain of the IL-12 receptor.

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Acknowledgments

We would like to thank the patient and her family, whose cooperation were essential for the collection of the data used in this publication. The principal author acknowledges Dr Lucie Seyler for kindly reviewing the manuscript and Esther van de Vosse for sharing data

Conflict of interest

We declare that we have no conflicts of interest.

Author information

Authors and Affiliations

  1. Immune Deficiencies Treatment Unit, ULB-Erasme, Brussels, Belgium

    Kinda Schepers, Jean-Paul Van Vooren & Jean-Christophe Goffard

  2. Immunobiology Clinic, Université Libre de Bruxelles, U.L.B., Brussels, Belgium

    Liliane Schandené & Françoise Mascart

  3. Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, U980, Paris, France

    Jacinta Bustamante, Maylis de Suremain & Jean-Laurent Casanova

  4. Sorbonne Paris Cité, Necker Medical Faculty, Paris Descartes University, Paris, France

    Jacinta Bustamante, Maylis de Suremain & Jean-Laurent Casanova

  5. Study Center for Primary Immunodeficiencies, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France

    Jacinta Bustamante

  6. St. Giles Laboratory of Human Genetic of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY, USA

    Jean-Laurent Casanova

  7. Department of Internal Medicine, Infectious and Tropical Diseases, Saint Luc University Hospital, Brussels, Belgium

    Jean Cyr Yombi

  8. Infectious Disease Unit, ULB-Erasme, Brussels, Belgium

    Frédérique Jacobs

  9. Hôpital Erasme, Service UTI, Route de Lennik 808, 1070, Brussels, Belgium

    Jean-Christophe Goffard

Authors
  1. Kinda Schepers
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  2. Liliane Schandené
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  3. Jacinta Bustamante
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  4. Jean-Paul Van Vooren
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  5. Maylis de Suremain
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  6. Jean-Laurent Casanova
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  7. Jean Cyr Yombi
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  8. Frédérique Jacobs
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  9. Françoise Mascart
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  10. Jean-Christophe Goffard
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Corresponding author

Correspondence to Jean-Christophe Goffard.

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Schepers, K., Schandené, L., Bustamante, J. et al. IL-12Rβ1 Deficiency and Disseminated Mycobacterium tilburgii Disease. J Clin Immunol 33, 1285–1288 (2013). https://doi.org/10.1007/s10875-013-9941-y

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  • DOI: https://doi.org/10.1007/s10875-013-9941-y

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