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Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organ Functions

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Abstract

Background

Epidemiological studies have demonstrated the relationship between Helicobacter pylori infection and gastric and extra-gastric diseases. Therefore, H. pylori infection might be a “systemic” disease.

Aim

To investigate the relationship between H. pylori infection status and serum parameter levels responding to multi-organ functions.

Methods

A total of 2,044 subjects were selected, including 1,249 males and 795 females with ages ranging from 16 to 86 years. Relevant parameters including blood lipids, complete blood count, tumor markers, indexes of stomach, kidney, liver, thyroid, and immune system function, H.pylori IgG antibody levels, and 14C-UBT were collected.

Results

Serum pepsinogen (PG)I, PGII, and gastrin (G)17 levels were decreased in chronic long-term, past, and acute short-term infection patients compared with uninfected controls. However, the serum PGI/II ratio increased gradually. Serum white blood cell levels gradually decreased in past, chronic long-term, and acute short-term infection patients compared with uninfected controls. The same trend was also observed for CD4+ T cell levels. In addition, LDL levels were higher in chronic long-term infection, HDL levels were lower in past infection, and ALP and CEA levels were higher in acute short-term infection compared with the uninfected group.

Conclusions

Helicobacter pylori infection correlated with increased PGI, PGII, G17, WBC, and CD4+ T cell levels, and decreased PGI/II ratio. In chronic long-term or past infection, H. pylori infection was associated with higher LDL or lower HDL levels. In acute short-term infection, H. pylori infection correlated with higher ALP and CEA levels. H. pylori infection correlated with serum parameter levels responding to multi-organ functions.

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Acknowledgments

This research was supported by the National Basic Research Development Program of China (973 Program No. 2010CB529304) and National Natural Science Foundation of China (No. 31000074). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Conflict of interest

None.

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Authors and Affiliations

  1. Department of Tumor Etiology and Screening, Cancer Institute and General Surgery, The First Affiliated Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention, Liaoning Provincial Education Department, 155 North Nanjing Street, Heping District, Shenyang, 110001, China

    Yuehua Gong, Liu Jingwei, Dong Nannan & Yuan Yuan

  2. Health Examination Center, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang, 110001, China

    Wang Wei

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  1. Yuehua Gong
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  2. Wang Wei
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Correspondence to Yuan Yuan.

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Gong, Y., Wei, W., Jingwei, L. et al. Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organ Functions. Dig Dis Sci 60, 1748–1754 (2015). https://doi.org/10.1007/s10620-015-3522-2

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