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Expression and Prognostic Roles of Eag1 in Resected Esophageal Squamous Cell Carcinomas

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Abstract

Expression of Eag1 was detected in resected esophageal squamous cell carcinomas tissues and matched tissues by immunohistochemistry and RT-PCR. Positive expression of Eag1 protein was 75% (51/68), and mRNA was 73% (8/11) in primary cancer tissues. Eag1 protein positively stained in all 10 metastatic lymph nodes. Eag1 protein and mRNA were negatively expressed in all non-cancerous matched tissues. Eag1 protein was associated with depth of penetration (P = 0.023), but not associated with other clinicopathological factors. Eag1 protein positive group had a significantly shorter survival time than the negative group (P = 0.005). Survival rates at each time-point for the positive group were lower than that for the negative group (P = 0.006), and Eag1 was identified as an independent prognostic factor of long-term survival (P = 0.016). In conclusion, Eag1 was aberrantly expressed in ESCC and correlated with poor prognosis after surgery.

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Acknowledgements

This work was supported by Xiangfan Central Hospital and Wuhan University.

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Authors and Affiliations

  1. Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan, 430060, P.R. China

    Xiang-Wu Ding, He-Sheng Luo & Shi-Yun Tan

  2. Department of Gastroenterology, Xiangfan Central Hospital, Xiangfan, Hubei Province, 441021, P.R. China

    Xiang-Wu Ding & Shan Gao

  3. Department of Education, Xiangfan Central Hospital, Xiangfan, Hubei Province, 441021, P.R. China

    Xiang-Gui Wang

  4. Department of Oncology, Xiangfan Central Hospital, Xiangfan, Hubei Province, 441021, P.R. China

    Bing Luo

  5. Department of Clinical Laboratory, Xiangfan Central Hospital, Xiangfan, Hubei Province, 441021, P.R. China

    Hua Jiang

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  1. Xiang-Wu Ding
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Correspondence to He-Sheng Luo.

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Ding, XW., Wang, XG., Luo, HS. et al. Expression and Prognostic Roles of Eag1 in Resected Esophageal Squamous Cell Carcinomas. Dig Dis Sci 53, 2039–2044 (2008). https://doi.org/10.1007/s10620-007-0116-7

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  • DOI: https://doi.org/10.1007/s10620-007-0116-7

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