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Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

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Abstract

Over the past 40 years, a significant body of animal and human research has documented the teratogenic effects of prenatal alcohol exposure (PAE). Neurobehavioral Disorder associated with PAE is proposed as a new clarifying term, intended to encompass the neurodevelopmental and mental health symptoms associated with PAE. Defining this disorder is a necessary step to adequately characterize these symptoms and allow clinical assessment not possible using existing physically-based diagnostic schemes. Without appropriate diagnostic guidelines, affected individuals are frequently misdiagnosed and treated inappropriately (often to their considerable detriment) by mental health, educational, and criminal justice systems. Three core areas of deficits identified from the available research, including neurocognitive, self-regulation, and adaptive functioning impairments, are discussed and information regarding associated features and disorders, prevalence, course, familial patterns, differential diagnosis, and treatment of the proposed disorder are also provided.

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Authors and Affiliations

  1. Departments of Psychiatry and Behavioral Sciences and Pediatrics, Emory University School of Medicine, Atlanta, GA, 30329, USA

    Julie A. Kable

  2. Department of Psychiatry and Behavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Mary J. O’Connor & Blair Paley

  3. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA

    Heather Carmichael Olson

  4. Department of Psychology, Center for Behavioral Teratology, San Diego State University, San Diego, CA, 92120, USA

    Sarah N. Mattson & Edward P. Riley

  5. National Institute on Alcohol Abuse and Alcoholism, Bethesda, MA, USA

    Sally M. Anderson

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  1. Julie A. Kable
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  2. Mary J. O’Connor
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  3. Heather Carmichael Olson
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  4. Blair Paley
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  5. Sarah N. Mattson
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  6. Sally M. Anderson
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  7. Edward P. Riley
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Correspondence to Julie A. Kable.

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Kable, J.A., O’Connor, M.J., Olson, H.C. et al. Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis. Child Psychiatry Hum Dev 47, 335–346 (2016). https://doi.org/10.1007/s10578-015-0566-7

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