Skip to main content

Advertisement

Log in

Additional effect of pulsed electromagnetic field therapy on knee osteoarthritis treatment: a randomized, placebo-controlled study

  • Brief Report
  • Published:
Clinical Rheumatology Aims and scope Submit manuscript

Abstract

The aim of this study was to evaluate if pulsed electromagnetic field therapy (PEMF) has additional effect on the classical physical treatment of knee osteoarthritis (OA) composed of hot pack, therapeutic ultrasound, and terminal isometric exercises. Forty patients (29 women and 11 men), ages 44 to 78 (mean age was 61.3 ± 7.8 years) were included in our study. Patients with knee osteoarthritis [Kellgren–Lawrence criteria grade 2 and above and an average pain intensity of 40 or more on a 100-mm visual analog scale (VAS)] recruited from outpatient physical medicine and rehabilitation clinic were randomly assigned to receive PEMF or sham PEMF treatment in addition to their physical therapy. Both the PEMF and sham PEMF treatments being evaluated were 55 min/session, five sessions per week for 2 weeks. Each session comprise 20-min hot pack, 5-min therapeutic ultrasound, and 30-min PEMF or sham PEMF treatment applied to the knee of the patients. Patients were evaluated by the Western Ontario and McMasters Universities Osteoarthritis (WOMAC) Index and VAS at the baseline and at the end of treatment. Both PEMF and sham PEMF treatment groups showed statistically significant improvement in WOMAC pain and functional scores at the end of treatment (p < 0.001 in both groups). There were no statistically significant differences between groups in WOMAC pain, stiffness, and physical function scores after treatment (p = 0.906, p = 0.855, p = 0.809, respectively). There was neither difference in concomitant used acetaminophen dose in both groups (p = 0.289). The results of this study show that PEMF does not have additional effect on the classical physical treatment in reducing symptoms of knee OA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. McCarthy CJ, Callaghan MJ, Oldham JA (2006) Pulsed electromagnetic energy treatment offers no clinical benefit in reducing the pain of knee osteoarthritis: a systematic review. BMC Musculoskelet Disord 51:1–5. doi:10.1186/s1471-2474-7-51

    Google Scholar 

  2. Pipitone N, Scott DL (2001) Magnetic pulse treatment for knee osteoarthritis: a randomised, double-blind, placebo-controlled study. Curr Med Res Opin 17:190–196. doi:10.1185/s03007-990-391170-61

    CAS  PubMed  Google Scholar 

  3. Thamsborg G, Florescu A, Oturai P, Fallentin E, Tritsaris K, Dissingi S (2005) Treatment of knee osteoarthritis with pulsed electromagnetic fields: a randomized, double-blind, placebo-controlled study. Osteoarthritis Cartilage 13:575–581. doi:10.1016/j.joca.2005.02.012

    Article  CAS  PubMed  Google Scholar 

  4. Trock DH, Bollet AJ, Dyer RH Jr, Fielding LP, Miner WK, Markoll R (1993) A double-blind trial of the clinical effects of pulsed electromagnetic fields in osteoarthritis. J Rheumatol 20:456–460

    CAS  PubMed  Google Scholar 

  5. Trock DH, Bollet AJ, Markoll R (1994) The effect of pulsed electromagnetic fields in the treatment of osteoarthritis of the knee and cervical spine. Report of randomized, double-blind, placebo-controlled trials. J Rheumatol 21:1903–1911

    CAS  PubMed  Google Scholar 

  6. Trock DH (2000) Electromagnetic fields and magnets. Investigational treatment for musculoskeletal disorders. Rheum Dis Clin North Am 26:51–62

    Article  CAS  PubMed  Google Scholar 

  7. Zizic TM, Hoffman KC, Holt PA, Hungerford DS, O’Dell JR, Jacobs MA et al (1995) The treatment of osteoarthritis of the knee with pulsed electrical stimulation. J Rheumatol 9:1757–1761

    Google Scholar 

  8. Sharma L (2002) Nonpharmacologic management of osteoarthritis. Curr Opin Rheumatol 14:603–607

    Article  PubMed  Google Scholar 

  9. Ciombor DM, Lester G, Aaron RK, Neame P, Caterson B (2002) Low frequency EMF regulates chondrocyte differentiation and expression of matrix proteins. J Orthop Res 1:40–50. doi:10.1016/s0736-0266(01)00071-7

    Article  Google Scholar 

  10. Tüzün EH, Eker L, Aytar A, Daşkapan A, Bayramoğlu M (2005) Acceptability, reliability, validity and responsiveness of the Turkish version of WOMAC osteoarthritis index. Osteoarthritis Cartilage 13:28–33. doi:10.1016/j.joca.2004.10.010

    Article  PubMed  Google Scholar 

  11. Ay S, Evcik D (2009) The effects of pulsed electromagnetic fields in the treatment of knee osteoarthritis: a randomized, placebo-controlled trial. Rheumatol Int 29:663–666. doi:10.1007/s00296-008-0754-x

    Article  PubMed  Google Scholar 

  12. Brazier JE, Harper R, Munro J, Walters SJ, Snaith ML (1999) Generic and condition-specific outcome measures for people with osteoarthritis of the knee. Rheumatology (Oxford) 38:870–877

    Article  CAS  Google Scholar 

  13. Atamaz F, Hepguler S, Oncu J (2005) Translation and validation of the Turkish version of the arthritis impact measurement scales 2 in patients with knee osteoarthritis. J Rheumatol 32:1331–1336

    PubMed  Google Scholar 

  14. Aaron RK, Boyan BD, Ciombor DM, Schwartz Z, Simon BJ (2004) Stimulation of growth factor synthesis by electric and electromagnetic fields. Clin Orthop 419:30–37

    Article  PubMed  Google Scholar 

  15. De Mattei M, Caruso A, Pezzetti F, Pellati A, StabelliniG SV (2001) Effects of pulsed electromagnetic fields on human articular chondrocyte proliferation. Connect Tissue Res 42:269–279

    Article  PubMed  Google Scholar 

  16. Pezzetti F, De Mattei M, Caruso A, Cadossi R, Zucchini P, Carinci F et al (1999) Effects of pulsed electromagnetic fields on human chondrocytes: an in vitro study. Calcif Tissue Int 65:396–401. doi:10.1007/s002239900720

    Article  CAS  PubMed  Google Scholar 

  17. Diniz P, Soejima K, Ito G (2002) Nitric oxide mediates the effects of pulsed electromagnetic field stimulation on the osteoblast proliferation and differentiation. Nitric Oxide 7:18–23

    Article  CAS  PubMed  Google Scholar 

  18. Aaron RK, Ciombor DMK (1996) Acceleration of experimental endochondral ossification by biophysical stimulation of the progenitor cell pool. J Orthop Res 14:582–589. doi:10.1002/jor.1100140412

    Article  CAS  PubMed  Google Scholar 

  19. Liu H, Lees P, Abbott J, Bee JA (1997) Pulsed electromagnetic fields preserve proteoglycan composition of extracellular matrix in embryonic chick sternal cartilage. Biochim Biophys Acta 2:303–314

    Google Scholar 

  20. Liu H, Abbott J, Bee JA (1996) Pulsed electromagnetic fields influence hyaline cartilage extracellular matrix composition without affecting molecular structure. Osteoarthritis Cartilage 1:63–76

    Article  Google Scholar 

  21. Fini M, Giavaresi G, Torricelli P, Cavani F, Setti S, Canè V, Giardino R (2005) Pulsed electromagnetic fields reduce knee osteoarthritic lesion progression in the aged Dunkin Hartley guinea pig. J Orthop Res 23:899–908. doi:10.1016/j.orthres.2005.01.008

    Article  CAS  PubMed  Google Scholar 

  22. Rogachefsky RA, Altman RD, Markov MS, Cheung HS (2004) Use of a permanent magnetic field to inhibit the development of canine osteoarthritis. Bioelectromagnetics 25:260–270. doi:10.1002/bem.10192

    Article  PubMed  Google Scholar 

  23. Fini M, Torricelli P, Giavaresi G, Aldini NN, Cavani F, Setti S, Nicolini A, Carpi A, Giardino R (2008) Effect of pulsed electromagnetic field stimulation on knee cartilage, subchondral and epyphiseal trabecular bone of aged Dunkin Hartley guinea pigs. Biomed Pharmacother 62:709–715. doi:10.1016/j.biopha.2007.03.001

    Article  PubMed  Google Scholar 

  24. De Mattei M, Pasello M, Pellati A, Stabellini G, Massari L, Gemmati D, Caruso A (2003) Effects of electromagnetic fields on proteoglycanmetabolism of bovine articular cartilage explants. Connect Tissue Res 44:154–159

    PubMed  Google Scholar 

  25. Ciombor DM, Aaron RK, Wang S, Simon B (2003) Modification of osteoarthritis by pulsed electromagnetic field a morphological study. Osteoarthritis Cartilage 11:455–462. doi:10.1016/s1063-4584(03)00083-9

    Article  PubMed  Google Scholar 

Download references

Disclosures

No conflict of interest has been declared by all authors.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Erkan Özgüçlü.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Özgüçlü, E., Çetin, A., Çetin, M. et al. Additional effect of pulsed electromagnetic field therapy on knee osteoarthritis treatment: a randomized, placebo-controlled study. Clin Rheumatol 29, 927–931 (2010). https://doi.org/10.1007/s10067-010-1453-z

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10067-010-1453-z

Keywords

Navigation