Abstract
Heterogeneities in the density of hepatitis C virus (HCV)-RNA-carrying material from human sera (1.03–1.20 g/ml) are partially due to the binding of lipoproteins [low density (LDL), very low density (VLDL), high density (HDL) lipoproteins] and immunoglobulins. In this study we demonstrate the binding of recombinant HCV envelope protein (E1/E2) to human LDL, VLDL and HDL on a molecular basis. The binding of lipoproteins was restricted to the middle part of the E1 gene product (amino acids 222–336) and the C-terminal part of the E2 protein (amino acids 523–809). Lipoproteins did not bind to recombinant HCV core protein.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 22 December 1999
Rights and permissions
About this article
Cite this article
Monazahian, M., Kippenberger, S., Müller, A. et al. Binding of human lipoproteins (low, very low, high density lipoproteins) to recombinant envelope proteins of hepatitis C virus. Med Microbiol Immunol 188, 177–184 (2000). https://doi.org/10.1007/s004300000032
Issue Date:
DOI: https://doi.org/10.1007/s004300000032