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Intravitreal triamcinolone for acute central retinal vein occlusion; a randomized clinical trial

  • Clinical Investigation
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Abstract

Background

Central retinal vein occlusion (CRVO) is the most common vascular event in the eye after diabetic retinopathy. This study was conducted to evaluate the effect of intravitreal triamcinolone (IVT) on acute CRVO.

Methods

In a randomized sham-controlled clinical trial, 27 eyes with recent onset (less than 2 months) CRVO were randomly assigned to two groups. The treatment group (13 eyes) received 4 mg IVT and the control group (14 eyes) received a sham subconjunctival injection. The outcomes were visual acuity (VA), occurrence of neovascularization of the iris (NVI), and central macular thickness (CMT) measured by optical coherence tomography. Examination was repeated 1, 2, 3, and 4 months after intervention.

Results

Mean (standard error) of CMT before, 2 and 4 months after injection was 565 (50), 259 (15), and 290 (53) microns in the treatment group and 629 (43), 470 (62) and 413 (59) microns in the sham group, respectively. The 2- month difference was significant (P=0.003). The difference between VA changes (0.39 logMAR) was significant only at 1 month (P=0.013). There was no meaningful difference in the occurrence of NVI between the two groups.

Conclusions

The therapeutic effect of IVT on acute CRVO is greatest at months 1 and 2 with regard to VA and macular thickness, respectively, and decreases up to the 4th month.

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Acknowledgement

This study was supported by the Ophthalmic Research Centre of Shaheed Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Ophthalmic Research Centre, Labbafinejad Medical Centre, Shaheed Beheshti University of Medical Sciences, Boostan 9 Avenue, Pasdaran Street, Tehran, 16666, Iran

    Alireza Ramezani, Morteza Entezari, Siamak Moradian, Homa Tabatabaei & Shohreh Kadkhodaei

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  1. Alireza Ramezani
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  2. Morteza Entezari
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  3. Siamak Moradian
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  4. Homa Tabatabaei
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  5. Shohreh Kadkhodaei
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Corresponding author

Correspondence to Alireza Ramezani.

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The authors have no interest in the materials presented in the study.

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Ramezani, A., Entezari, M., Moradian, S. et al. Intravitreal triamcinolone for acute central retinal vein occlusion; a randomized clinical trial. Graefe's Arch Clin Exp Ophthalmol 244, 1601–1606 (2006). https://doi.org/10.1007/s00417-006-0348-9

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  • DOI: https://doi.org/10.1007/s00417-006-0348-9

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