Abstract
Fusobacterium necrophorum (FN) is the predominant pathogen in peritonsillar abscesses, which is a relatively frequent complication of acute tonsillitis. The study aimed to explore if FN is a significant pathogen in acute tonsillitis, examine the prevalence of FN in acute tonsillitis patients, and describe the clinical and biochemical characteristics of FN-positive patients. A 6-month prospective study was conducted in a Danish general practice with eight physicians. One hundred acute tonsillitis patients and 100 healthy controls aged 15–40 years were included in the study. The prevalence of FN was (non-significantly) higher among acute tonsillitis patients (16 %) compared to healthy individuals (9 %) (P = 0.199). This trend was border significant for patients aged 15–29 years (24 vs 9 %) (P = 0.050). Significantly, more FN-positive patients were men (75 %) compared to patients growing other bacteria (17 %) or mixed oral flora (27 %) (P < 0.001). Centor scores, individual clinical symptoms, and infection markers were similar between patient growing FN and mixed oral flora. FN is possibly a significant and prevalent pathogen in acute tonsillitis among teenagers and young adults. Patients with FN-positive acute tonsillitis do not seem to be more clinically or biochemically affected than patients without growth of bacterial pathogens.
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Fine AM, Nizet V, Mandl KD (2012) Large-scale validation of the Centor and McIsaac scores to predict group A streptococcal pharyngitis. Arch Intern Med 172(11):847–852
Batty A, Wren MWD (2005) Prevalence of Fusobacterium necrophorum and other upper respiratory tract pathogens isolated from throat swabs. Br J Biomed Sci 62(2):66–70
Amess JA, O’Neill W, Giollariabhaigh CN, Dytrych JK (2007) A six-month audit of the isolation of Fusobacterium necrophorum from patients with sore throat in a district general hospital. Br J Biomed Sci 64(2):63–65
Del Mar CB, Glasziou PP, Spinks AB (2006) Antibiotics for sore throat. Cochrane Database Syst Rev 4:CD000023
Centor RM, Witherspoon JM, Dalton HP, Brody CE, Link K (1981) The diagnosis of strep throat in adults in the emergency room. Med Decis Making 1(3):239–246
McIsaac WJ, Kellner JD, Aufricht P, Vanjaka A, Low DE (2004) Empirical validation of guidelines for the management of pharyngitis in children and adults. JAMA 291(13):1587–1595
Bourbeau PP (2003) Role of the microbiology laboratory in diagnosis and management of pharyngitis. J Clin Microbiol 41(8):3467–3472
Ehlers Klug T, Rusan M, Fuursted K, Ovesen T (2009) Fusobacterium necrophorum: most prevalent pathogen in peritonsillar abscess in Denmark. Clin Infect Dis 49(10):1467–1472
Hagelskjaer LH, Prag J, Malczynski J, Kristensen JH (1998) Incidence and clinical epidemiology of necrobacillosis, including Lemierre’s syndrome, in Denmark 1990–1995. Eur J Clin Microbiol Infect Dis 17(8):561–565
Klug TE, Henriksen J-J, Fuursted K, Ovesen T (2010) Significant pathogens in peritonsillar abscesses. Eur J Clin Microbiol Infect Dis 30(5):619–627
Aliyu SH, Marriott RK, Curran MD, Parmar S, Bentley N, Brown NM, Brazier JS, Ludlam H (2004) Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice. J Med Microbiol 53(Pt 10):1029–1035
Jensen A, Hagelskjaer Kristensen L, Prag J (2007) Detection of Fusobacterium necrophorum subsp. funduliforme in tonsillitis in young adults by real-time PCR. Clin Microbiol Infect 13(7):695–701
Eaton C, Swindells J (2014) The significance and epidemiology of Fusobacterium necrophorum in sore throats. J Infect 69(2):194–196
Klug TE (2014) Incidence and microbiology of peritonsillar abscess: the influence of season, age, and gender. Eur J Clin Microbiol Infect Dis. doi:10.1007/s10096-014-2052-8
Fourage M, Bourguignat C, Fermond B, Delobel P (2013) A recurrent tonsillitis. Lancet 381(9862):266
Centor RM, Geiger P, Waites KB (2010) Fusobacterium necrophorum bacteremic tonsillitis: 2 cases and a review of the literature. Anaerobe 16(6):626–628
Brook I (2005) The association of anaerobic bacteria with infectious mononucleosis. Anaerobe 11(6):308–311
Gehrt B, Jensen A, Kristensen LH, Prag J (2009) Can anaerobic culture of throat swabs prevent Lemierre’s syndrome? Ugeskr Laeg 171(12):991–992
Hagelskjaer Kristensen L, Prag J (2008) Localised Fusobacterium necrophorum infections: a prospective laboratory-based Danish study. Eur J Clin Microbiol Infect Dis 27(8):733–739
Klug TE, Rusan M, Clemmensen KKB, Fuursted K, Ovesen T (2013) Smoking promotes peritonsillar abscess. Eur Arch Otorhinolaryngol. doi:10.1007/s00405-013-2474-4
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The authors are thankful to Skoedstrup general practice, 8541 Skoedstrup, Denmark for providing facilities available in the recruitment of patients.
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The authors declare that they have no conflict of interest.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Kjærulff, A.M.G., Thomsen, M.K., Ovesen, T. et al. Clinical and biochemical characteristics of patients with Fusobacterium necrophorum-positive acute tonsillitis. Eur Arch Otorhinolaryngol 272, 1457–1463 (2015). https://doi.org/10.1007/s00405-015-3535-7
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DOI: https://doi.org/10.1007/s00405-015-3535-7