Skip to main content
Log in

Acute ventilatory restriction in children after weaning off inhaled nitric oxide: relation to rebound pulmonary hypertension

  • NEONATAL AND PEDIATRIC INTENSIVE CARE
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

Objective: To assess the interaction between pulmonary hemodynamics and respiratory mechanics during acute pulmonary hypertension. Patients: Ventilated and paralysed children treated with inhaled nitric oxide because of post-operative pulmonary hypertension. Interventions: Weaning of inhaled nitric oxide. Measurements: Air flow and airway pressure, calculation of dynamic respiratory system compliance and respiratory system resistance for each breath by multiple linear regression. Results: In four patients, increases in pulmonary arterial pressure from 26.1 to 56.7 mmg (p < 0.001) during weaning off nitric oxide were associated with decreases in tidal volume (from 9.7 → 8.2 ml/kg, p < 0.01) and reductions in dynamic respiratory system compliance (from 0.52 → 0.34 cmH20/ml/kg, p < 0.001), while respiratory system resistance was unchanged. Conclusions: Impaired ventilation during acute pulmonary hypertension is predominantly related to a reduction in respiratory system compliance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 26 March 1998 Final revision received: 9 June 1998 Accepted: 30 July 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schulze-Neick, I., Werner, H., Penny, D. et al. Acute ventilatory restriction in children after weaning off inhaled nitric oxide: relation to rebound pulmonary hypertension. Intensive Care Med 25, 76–80 (1999). https://doi.org/10.1007/s001340050790

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s001340050790

Navigation