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Chronic Pain Following Spinal Cord Injury

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Regenerative Biology of the Spine and Spinal Cord

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 760))

Abstract

Most patients with insults to the spinal cord or central nervous system suffer from excruciating, unrelenting, chronic pain that is largely resistant to treatment. This condition affects a large percentage of spinal cord injury patients, and numerous patients with multiple sclerosis, stroke and other conditions. Despite the recent advances in basic science and clinical research the pathophysiological mechanisms of pain following spinal cord injury remain unknown. Here we describe a novel mechanism of loss of inhibition within the thalamus that may predispose for the development of this chronic pain and discuss a potential treatment that may restore inhibition and ameliorate pain.

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Authors and Affiliations

  1. Department of Endodontics, Prosthodontics and Operative Dentistry, Baltimore College of Dental Surgery, University of Maryland Baltimore, Baltimore, Maryland, USA

    Radi Masri

  2. Department of Anatomy and Neurobiology, Medical School, University of Maryland Baltimore, Baltimore, Maryland, USA

    Radi Masri & Asaf Keller

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  1. Radi Masri
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  2. Asaf Keller
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Editors and Affiliations

  1. Division of Neurosurgery, City of Hope Cancer Center and Beckman Research Institute, Los Angeles, California, USA

    Rahul Jandial MD, PhD  & Mike Y. Chen MD, PhD  & 

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Masri, R., Keller, A. (2012). Chronic Pain Following Spinal Cord Injury. In: Jandial, R., Chen, M.Y. (eds) Regenerative Biology of the Spine and Spinal Cord. Advances in Experimental Medicine and Biology, vol 760. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-4090-1_5

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