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Randomized clinical trial
- Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS)Jessica Mandrioli, Valeria Crippa, Cristina Cereda, Valentina Bonetto, Elisabetta Zucchi, Annalisa Gessani, Mauro Ceroni, Adriano Chio, Roberto D’Amico, Maria Rosaria Monsurrò, Nilo Riva, Mario Sabatelli, Vincenzo Silani, Isabella Laura Simone, Gianni Sorarù, Alessandro Provenzani, Vito Giuseppe D’Agostino, Serena Carra, Angelo PolettiBMJ Open May 2019, 9 (5) e028486; DOI: 10.1136/bmjopen-2018-028486
- Effects of menaquinone-7 supplementation in patients with aortic valve calcification: study protocol for a randomised controlled trialJes Sanddal Lindholt, Niels Erik Frandsen, Maise Høigaard Fredgart, Kristian A Øvrehus, Jordi Sanchez Dahl, Jacob Eifer Møller, Lars Folkestad, Grazina Urbonaviciene, Søren Warberg Becker, Jess Lambrechtsen, Søren Auscher, Susanne Hosbond, Dilek Hunerel Alan, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, Axel DiederichsenBMJ Open Aug 2018, 8 (8) e022019; DOI: 10.1136/bmjopen-2018-022019
- Clinical effectiveness of patella mobilisation therapy versus a waiting list control for knee osteoarthritis: a protocol for a pragmatic randomised clinical trialRegina Wing Shan Sit, Keith Kwok Wai Chan, Benjamin Hon Kei Yip, Daisy Dexing Zhang, Kenneth Dean Reeves, Ying Ho Chan, Vincent Chi Ho Chung, Samuel Yeung Shan WongBMJ Open Mar 2018, 8 (3) e019103; DOI: 10.1136/bmjopen-2017-019103
- High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trialKatalin Márta, Anikó N Szabó, Dániel Pécsi, Péter Varjú, Judit Bajor, Szilárd Gódi, Patrícia Sarlós, Alexandra Mikó, Kata Szemes, Mária Papp, Tamás Tornai, Áron Vincze, Zsolt Márton, Patrícia A Vincze, Erzsébet Lankó, Andrea Szentesi, Tímea Molnár, Roland Hágendorn, Nándor Faluhelyi, István Battyáni, Dezső Kelemen, Róbert Papp, Attila Miseta, Zsófia Verzár, Markus M Lerch, John P Neoptolemos, Miklós Sahin-Tóth, Ole H Petersen, Péter HegyiBMJ Open Sep 2017, 7 (9) e015874; DOI: 10.1136/bmjopen-2017-015874
- Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)Eleonora Dalla Bella, Irene Tramacere, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Roberto Eleopra, Massimiliano Filosto, Fabio Giannini, Enrico Granieri, Vincenzo La Bella, Christian Lunetta, Jessica Mandrioli, Letizia Mazzini, Sonia Messina, Maria Rosaria Monsurrò, Gabriele Mora, Nilo Riva, Romana Rizzi, Gabriele Siciliano, Vincenzo Silani, Isabella Simone, Gianni Sorarù, Paolo Volanti, Giuseppe LauriaBMJ Open Aug 2017, 7 (8) e015434; DOI: 10.1136/bmjopen-2016-015434
- Low-glycaemic index diet to improve glycaemic control and cardiovascular disease in type 2 diabetes: design and methods for a randomised, controlled, clinical trialLaura Chiavaroli, Arash Mirrahimi, Christopher Ireland, Sandra Mitchell, Sandhya Sahye-Pudaruth, Judy Coveney, Omodele Olowoyeye, Tishan Maraj, Darshna Patel, Russell J de Souza, Livia S A Augustin, Balachandran Bashyam, Sonia Blanco Mejia, Stephanie K Nishi, Lawrence A Leiter, Robert G Josse, Gail McKeown-Eyssen, Alan R Moody, Alan R Berger, Cyril W C Kendall, John L Sievenpiper, David J A JenkinsBMJ Open Jul 2016, 6 (7) e012220; DOI: 10.1136/bmjopen-2016-012220
- Default options in advance directives: study protocol for a randomised clinical trialNicole B Gabler, Elizabeth Cooney, Dylan S Small, Andrea B Troxel, Robert M Arnold, Douglas B White, Derek C Angus, George Loewenstein, Kevin G Volpp, Cindy L Bryce, Scott D HalpernBMJ Open Jun 2016, 6 (6) e010628; DOI: 10.1136/bmjopen-2015-010628
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