Immunology

Population differences in vaccine responses (POPVAC): scientific rationale and cross-cutting analyses for three linked, randomised controlled trials assessing the role, reversibility and mediators of immunomodulation by chronic infections in the tropics
Gyaviira Nkurunungi, Ludoviko Zirimenya, Agnes Natukunda, Jacent Nassuuna, Gloria Oduru, Caroline Ninsiima, Christopher Zziwa, Florence Akello, Robert Kizindo, Mirriam Akello, Pontiano Kaleebu, Anne Wajja, Henry Luzze, Stephen Cose, Emily Webb, Alison M Elliott

BMJ Open Dec 2020, 11 (2) e040425; DOI: 10.1136/bmjopen-2020-040425
Effect of intensive treatment for schistosomiasis on immune responses to vaccines among rural Ugandan island adolescents: randomised controlled trial protocol A for the ‘POPulation differences in VACcine responses’ (POPVAC) programme
Gyaviira Nkurunungi, Ludoviko Zirimenya, Jacent Nassuuna, Agnes Natukunda, Prossy N Kabuubi, Emmanuel Niwagaba, Gloria Oduru, Grace Kabami, Rebecca Amongin, Alex Mutebe, Milly Namutebi, Christopher Zziwa, Susan Amongi, Caroline Ninsiima, Caroline Onen, Florence Akello, Moses Sewankambo, Samuel Kiwanuka, Robert Kizindo, James Kaweesa, Stephen Cose, Emily Webb, Alison M Elliott

BMJ Open Feb 2021, 11 (2) e040426; DOI: 10.1136/bmjopen-2020-040426
Effect of intermittent preventive treatment for malaria with dihydroartemisinin-piperaquine on immune responses to vaccines among rural Ugandan adolescents: randomised controlled trial protocol B for the ‘POPulation differences in VACcine responses’ (POPVAC) programme
Agnes Natukunda, Gyaviira Nkurunungi, Ludoviko Zirimenya, Jacent Nassuuna, Gloria Oduru, Rebecca Amongin, Prossy N Kabuubi, Alex Mutebe, Caroline Onen, Susan Amongi, Esther Nakazibwe, Florence Akello, Samuel Kiwanuka, Fred Kiwudhu, Moses Sewankambo, Denis Nsubuga, Robert Kizindo, Sarah G Staedke, Stephen Cose, Emily Webb, Alison M Elliott

BMJ Open Dec 2020, 11 (2) e040427; DOI: 10.1136/bmjopen-2020-040427
Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled trial (IgM-fat trial)
Emanuela Biagioni, Martina Tosi, Giorgio Berlot, Giacomo Castiglione, Alberto Corona, Maria Giovanna De Cristofaro, Abele Donati, Paolo Feltracco, Francesco Forfori, Fiorentino Fragranza, Patrizia Murino, Ornella Piazza, Livio Tullo, Giacomo Grasselli, Roberto D'Amico, Massimo Girardis

BMJ Open Feb 2021, 11 (2) e036616; DOI: 10.1136/bmjopen-2019-036616
Seroprevalence of SARS-CoV-2 in the West Bank region of Palestine: a cross-sectional seroepidemiological study
Nouar Qutob, Faisal Awartani, Zaidoun Salah, Mohammad Asia, Imad Abu Khader, Khaled Herzallah, Nadeen Balqis, Husam Sallam

BMJ Open Feb 2021, 11 (2) e044552; DOI: 10.1136/bmjopen-2020-044552
RAISE study protocol: a cross-sectional, multilevel, neurobiological study of resilience after individual stress exposure
Laura Moreno-López, Samantha N Sallie, Konstantinos Ioannidis, Muzaffer Kaser, Katja Schueler, Adrian Dahl Askelund, Lorinda Turner, Anne-Laura van Harmelen

BMJ Open Jan 2021, 11 (1) e040394; DOI: 10.1136/bmjopen-2020-040394
Prospective validation study of prognostic biomarkers to predict adverse outcomes in patients with COVID-19: a study protocol
Benjamin Tang, Maryam Shojaei, Ya Wang, Marek Nalos, Anthony Mclean, Ali Afrasiabi, Tim N Kwan, Win Sen Kuan, Yoann Zerbib, Velma Herwanto, Gunawan Gunawan, Davide Bedognetti, Gabriele Zoppoli, Alberto Ballestrero, Darawan Rinchai, Paolo Cremonesi, Michele Bedognetti, Martin Matejovic, Thomas Karvunidis, Stephen P J Macdonald, Amanda J Cox, Nicholas P West, Allan William Cripps, Klaus Schughart, Andrea de Maria, Damien Chaussabel, Jonathan Iredell, Stephen Weng

BMJ Open Jan 2021, 11 (1) e044497; DOI: 10.1136/bmjopen-2020-044497
Assessing seropositivity for IgG antibodies against SARS-CoV-2 in Ahmedabad city of India: a cross-sectional study
Om Prakash, Bhavin Solanki, Jay K Sheth, Bhavin Joshi, Mina Kadam, Sheetal Vyas, Aparajita Shukla, Hemant Tiwari, Sanjay Rathod, Anil Rajput, Toral Trivedi, Vaibhav Ramanuj, Anand Solanki

BMJ Open Jan 2021, 11 (1) e044101; DOI: 10.1136/bmjopen-2020-044101
Efficacy and safety of mesenchymal stem cells for the treatment of patients infected with COVID-19: a systematic review and meta-analysis protocol
Yunhui Chen, Qing Zhang, Wei Peng, Dan Liu, Yanyan You, Xinglong Liu, Songqi Tang, Tiane Zhang

BMJ Open Dec 2020, 10 (12) e042085; DOI: 10.1136/bmjopen-2020-042085
OPTIMUM study protocol: an adaptive randomised controlled trial of a mixed whole-cell/acellular pertussis vaccine schedule
Gladymar Perez Chacon, Marie J Estcourt, James Totterdell, Dianne E Campbell, Kirsten P Perrett, Julie A Marsh, Peter C Richmond, Nicholas Wood, Michael S Gold, Patrick G Holt, Claire S Waddington, Thomas L Snelling

BMJ Open Dec 2020, 10 (12) e042838; DOI: 10.1136/bmjopen-2020-042838

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