development failure

Failures to further developing orphan medicinal products after designation granted in Europe: an analysis of marketing authorisation failures and abandoned drugs
Viviana Giannuzzi, Annalisa Landi, Enrico Bosone, Floriana Giannuzzi, Stefano Nicotri, Josep Torrent-Farnell, Fedele Bonifazi, Mariagrazia Felisi, Donato Bonifazi, Adriana Ceci

BMJ Open Sep 2017, 7 (9) e017358; DOI: 10.1136/bmjopen-2017-017358

CLINICAL
- Anaesthesia
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  - Eating disorders
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  - Memory disorders (psychiatry) (9)
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- Radiology (13)
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- Renal medicine
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  - Vascular surgery (1)
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NON-CLINICAL
- Communication (2)
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  - Ethics of reproduction
  - Experiments in vivo
  - Informed consent (8)
  - Research and publication ethics (16)
  - Sexuality / gender
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- Health informatics
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  - Internet (8)
  - IT (1)
  - Telemedicine
- Health policy (16)
- Health service research (12)
- Healthcare improvement and patient safety
- Journalology (10)
- Legal and forensic medicine (8)
- Medical careers
  - Continuous professional development
  - Getting and changing jobs (including job descriptions and contracts)
  - Professional conduct and regulation
- Medical education
  - History taking and the physical examination
  - Postgraduate
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- Medical humanities (2)
- Medical management
  - Doctors' morale and well being
  - Medical error/ patient safety (4)
  - Quality improvement (1)
- Occupational and environmental medicine
- Patients (5)
- Public health
  - Abuse (child, partner, elder)
  - Air pollution (1)
  - Alcohol
  - Drug misuse (1)
  - Environmental issues (3)
  - Health education (34)
  - Health of indigenous peoples
  - Health promotion (38)
  - Homicide (1)
  - Housing and health
  - Human rights
  - Injury (1)
  - Obesity (public health) (13)
  - Screening (public health) (15)
  - Sexual health (public health)
  - Smoking (20)
  - Social conditions and disease
  - Suicide (public health)
  - Urban health
  - Vaccination programs (3)
  - Violence (other)
  - Violence against women
- Smoking and tobacco (20)
- Sociology
- Statistics and research methods
  - Qualitative research
  - Quantitative research
Special collections
- BMJ Open
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  - Dentistry and oral medicine (54)
  - Dermatology (63)
  - Diabetes and Endocrinology (418)
  - Diagnostics (215)
  - Ear, nose and throat/otolaryngology (74)
  - Emergency medicine (299)
  - Endocrinology
  - Epidemiology (2152)
  - Ethics (83)
  - Evidence based practice (736)
  - Gastroenterology and hepatology (210)
  - General practice / Family practice (667)
  - Genetics and genomics (111)
  - Geriatric medicine (300)
  - Global health (460)
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  - Haematology (incl blood transfusion) (55)
  - Health economics (364)
  - Health economics (217)
  - Health informatics (213)
  - Health policy (673)
  - Health policy (447)
  - Health services research (1498)
  - HIV AIDS (187)
  - Immunology (including allergy) (60)
  - Infectious diseases (580)
  - Intensive care (198)
  - Legal and forensic medicine (16)
  - Medical education and training (277)
  - Medical management (228)
  - Medical publishing and peer review (74)
  - Mental health (717)
  - Mental health (449)
  - Neurology (423)
  - Nursing (135)
  - Nutrition and metabolism (330)
  - Nutrition and metabolism (213)
  - Obgyn (353)
  - Occupational and environmental medicine (288)
  - Oncology (427)
  - Oncology (277)
  - Ophthalmology (107)
  - Paediatrics (643)
  - Palliative care (77)
  - Pathology (41)
  - Patient-centred medicine (474)
  - Pharmacology and therapeutics (448)
  - Pharmacology and therapeutics (340)
  - Public health (2269)
  - Public health (1483)
  - Qualitative research (714)
  - Radiology and imaging (113)
  - Rehabilitation medicine (311)
  - Renal medicine (141)
  - Reproductive medicine (49)
  - Research methods (615)
  - Respiratory medicine (351)
  - Respiratory medicine (241)
  - Rheumatology (168)
  - Sexual health (153)
  - Smoking and tobacco (250)
  - Sociology (107)
  - Sports and exercise medicine (221)
  - Surgery (402)
  - Urology (74)
  - Video abstracts
- Guidelines, Recommendations and Consensus Statements
- Press releases (134)

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development failure