Clinical Pharmacology

Prospective evaluation of improving fluoroquinolone exposure using centralised therapeutic drug monitoring (TDM) in patients with tuberculosis (PERFECT): a study protocol of a prospective multicentre cohort study
Simone HJ van den Elsen, Marieke GG Sturkenboom, Onno Akkerman, Linda Barkane, Judith Bruchfeld, Geoffrey Eather, Scott K Heysell, Henadz Hurevich, Liga Kuksa, Heinke Kunst, Johanna Kuhlin, Katerina Manika, Charalampos Moschos, Stellah G Mpagama, Marcela Muñoz Torrico, Alena Skrahina, Giovanni Sotgiu, Marina Tadolini, Simon Tiberi, Francesca Volpato, Tjip S van der Werf, Malcolm R Wilson, Joaquin Zúñiga, Daan J Touw, Giovanni B Migliori, Jan-Willem Alffenaar

BMJ Open Jun 2020, 10 (6) e035350; DOI: 10.1136/bmjopen-2019-035350
Study protocol for an exploratory interventional study investigating the feasibility of video-based non-contact physiological monitoring in healthy volunteers by Mapping Of Lower Limb skIn pErfusion (MOLLIE)
Mirae Harford, Carlos Areia, Mauricio Villarroel, Joao Jorge, Eoin Finnegan, Shaun Davidson, Adam Mahdi, Duncan Young, Lionel Tarassenko, Peter J Watkinson

BMJ Open Jun 2020, 10 (6) e036235; DOI: 10.1136/bmjopen-2019-036235
Variation in the estimated costs of pivotal clinical benefit trials supporting the US approval of new therapeutic agents, 2015–2017: a cross-sectional study
Thomas J Moore, James Heyward, Gerard Anderson, G Caleb Alexander

BMJ Open Jun 2020, 10 (6) e038863; DOI: 10.1136/bmjopen-2020-038863
Anlotinib combined with SOX regimen (S1 (tegafur, gimeracil and oteracil porassium capsules) + oxaliplatin) in treating stage IV gastric cancer: study protocol for a single-armed and single-centred clinical trial
Juan Wang, Dong Xue Wu, Lu Meng, Gang Ji

BMJ Open Jun 2020, 10 (6) e034685; DOI: 10.1136/bmjopen-2019-034685
Has the introduction of direct oral anticoagulants (DOACs) in England increased emergency admissions for bleeding conditions? A longitudinal ecological study
Ana Alfirevic, Jennifer Downing, Konstantinos Daras, Terence Comerford, Munir Pirmohamed, Ben Barr

BMJ Open May 2020, 10 (5) e033357; DOI: 10.1136/bmjopen-2019-033357
Investigating the effect of clinical pharmacist intervention in transitions of care on drug-related hospital readmissions among the elderly: study protocol for a randomised controlled trial
Jonas Kindstedt, Sofia Svahn, Maria Sjölander, Eva-Lotta Glader, Hugo Lövheim, Maria Gustafsson

BMJ Open Apr 2020, 10 (4) e036650; DOI: 10.1136/bmjopen-2019-036650
Incidence, types and acceptability of pharmaceutical interventions about drug related problems in a general hospital: an open prospective cohort
Valdjane Saldanha, Rand Randall Martins, Sara Iasmin Vieira Cunha Lima, Ivonete Batista de Araujo, Antonio Gouveia Oliveira

BMJ Open Apr 2020, 10 (4) e035848; DOI: 10.1136/bmjopen-2019-035848
Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria
Cyril Erameh, Osahogie Edeawe, Peter Akhideno, Gloria Eifediyi, Till F Omansen, Christine Wagner, Francisca Sarpong, Till Koch, Sebastian Wicha, Florian Kurth, Sophie Duraffour, Lisa Oestereich, Meike Pahlmann, Sylvanus Okogbenin, Ephraim Ogbaini-Emovon, Stephan Günther, Michael Ramharter, Mirjam Groger

BMJ Open Apr 2020, 10 (4) e036936; DOI: 10.1136/bmjopen-2020-036936
Short-term PsychoEducation for Carers To Reduce Over Medication of people with intellectual disabilities (SPECTROM): study protocol
Shoumitro Deb, Bharati Limbu, Mike Crawford, Tim Weaver

BMJ Open Apr 2020, 10 (4) e037912; DOI: 10.1136/bmjopen-2020-037912
Severity of coeliac disease and clinical management study when using a CYP3A4 metabolised medication: a phase I pharmacokinetic study
Marc L Chretien, David G Bailey, Linda Asher, Jeremy Parfitt, David Driman, Jamie Gregor, George K Dresser

BMJ Open Mar 2020, 10 (3) e034086; DOI: 10.1136/bmjopen-2019-034086

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