Table 3

Net benefit regression results

(A) WOMAC
WTP*Healthcare payer†Societal†
Incremental net benefit95% CI, p valueIncremental net benefit95% CI, p value
0−1179.20 (386.56)−1942.58 to −415.82, <0.01−1670.507 (662.18)−2978.30 to −362.71, 0.01
1500−352418.73 (332804.27)−1009643.31 to 304805.85, 0.29−369151.74 (334686.56)−1030156.42 to 291852.95, 0.27
2000−469498.57 (443753.31)−1345826.20 to 406829.05, 0.29−491645.48 (446248.44)−1372984.45 to 389693.49, 0.27
2500−586578.42 (554702.36)−1682009.13 to 508852.29, 0.29−614139.22 (557810.37)−1715812.60 to 487534.16, 0.27
5000−1171977.63 (1109447.72)−3362923.98 to 1018968.72, 0.29−1226607.94 (1115620.38)−3429953.97 to 976738.10, 0.27
10 000−2342776.07 (2218938.56)−6724753.89 to 2039201.76, 0.29−2451545.36 (2231240.70)−6858237.29 to 1955146.56, 0.27
20 000−4684372.93 (4437920.28)−13448413.80 to 4079667.94, 0.29−4901420.22 (4462481.46)−13714804.20 to 3911963.77, 0.27
30 000−7025969.80 (6656902.01)−20172073.70 to 6120134.15, 0.29−7351295.08 (6693722.26)−20571371.20 to 5868871.04, 0.27
40 000−9367566.66 (8875883.74)−26895733.70 to 8160600.36, 0.29−9801169.94 (8924963.07)−27427938.20 to 7825598.33, 0.27
50 000−11709163.50 (11094865.47)−33619393.60 to 10201066.58, 0.29−12251044.80 (11156203.89)−34284505.20 to 9782415.63, 0.27
60 000−14050760.40 (13313847.20)−40343053.60 to 12241532.79, 0.29−14700919.70 (13387444.70)−41141072.20 to 11739232.93, 0.27
70 000−16392357.30 (15532828.94)−47066713.50 to 14281999.01, 0.29−17150794.50 (15618685.51)−47997639.20 to 13696050.23, 0.27
80 000−18733954.10 (17751810.67)−53790373.50 to 16322465.23, 0.29−19600669.40 (17849926.33)−54854206.30 to 15652867.53, 0.27
90 000−21075551.00 (19970792.40)−60514033.40 to 18362931.44, 0.29−22050544.20 (20081167.14)−61710773.30 to 17609684.84, 0.27
100 000−23417147.90 (22189774.14)−67237693.40 to 20403397.66, 0.29−24500419.10 (22312407.96)−68567340.30 to 19566502.14, 0.27
(B) QALY
WTP‡Healthcare payer†Societal†
Incremental net benefit95% CI, p valueIncremental net benefit95% CI, p value
0−2020.18 (558.61)−3123.38 to −916.98, <0.01−2048.89 (946.17)−3917.66 to −180.11, 0.03
1500−2226.59 (608.74)−3427.75 to −1023.38, <0.01−2250.38 (1006.93)−4239.15 to −261.59, 0.03
2000−2294.02 (645.94)−3569.69 to −1018.34, <0.01−2317.54 (1039.73)−4371.10 to −263.98, 0.03
2500−2362.48 (691.03)−3727.19 to −997.77, <0.01−2384.70 (1077.94)−4513.73 to −255.67, 0.03
5000−2704.77 (991.35)−4662.60 to −746.96, 0.01−2720.52 (1331.67)−5350.69 to −90.34 0.04
10 000−3389.38 (1735.70)−6817.21 to 38.45, 0.05−3392.14 (2007.52)−7357.19 to 572.91, 0.09
20 000−4758.57 (3339.13)−11353.01 to 1835.87, 0.16−4735.40 (3560.87)−11768.45 to 2297.66, 0.18
30 000−6127.77 (4972.26)−15947.50 to 3691.96, 0.22−6078.65 (5181.15)−16311.90 to 4154.60, 0.24
40 000−7496.98 (6613.14)−20557.26 to 5563.32, 0.26−7452.72 (6820.82)−20893.66 to 6049.85, 0.28
50 000−8866.17 (8257.13)−25173.19 to 7440.86, 0.29−8765.16 (8468.63)−25491.49 to 7961.16, 0.30
60 000−10235.37 (9902.70)−29792.22 to 9321.50, 0.30−10108.42 (10120.60)−30097.54 to 9880.70, 0.32
70 000−11604.56 (11549.16)−34413.03 to 11203.90, 0.32−11451.68 (11774.98)−34708.34 to 11804.99, 0.33
80 000−12973.76 (13196.19)−39034.94 to 13087.42, 0.33−12794.93 (13430.88)−39322.15 to 13732.30, 0.34
90 000−14342.96 (14843.59)−43657.60 to 14971.67, 0.34−14138.19 (15087.81)−43937.98 to 15661.62, 0.35
100 000−15712.16 (16491.26)−48280.77 to 16856.45, 0.34−15481.44 (16745.45)−48555.23 to 17592.53, 0.36
  • *WTP for a one-point improvement on the WOMAC total score.

  • †Incremental net benefit (SE).

  • ‡WTP for an additional QALY.

  • QALY, quality-adjusted life year; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; WTP, willingness-to-pay.