(A) WOMAC | ||||
---|---|---|---|---|
WTP* | Healthcare payer† | Societal† | ||
Incremental net benefit | 95% CI, p value | Incremental net benefit | 95% CI, p value | |
0 | −1179.20 (386.56) | −1942.58 to −415.82, <0.01 | −1670.507 (662.18) | −2978.30 to −362.71, 0.01 |
1500 | −352418.73 (332804.27) | −1009643.31 to 304805.85, 0.29 | −369151.74 (334686.56) | −1030156.42 to 291852.95, 0.27 |
2000 | −469498.57 (443753.31) | −1345826.20 to 406829.05, 0.29 | −491645.48 (446248.44) | −1372984.45 to 389693.49, 0.27 |
2500 | −586578.42 (554702.36) | −1682009.13 to 508852.29, 0.29 | −614139.22 (557810.37) | −1715812.60 to 487534.16, 0.27 |
5000 | −1171977.63 (1109447.72) | −3362923.98 to 1018968.72, 0.29 | −1226607.94 (1115620.38) | −3429953.97 to 976738.10, 0.27 |
10 000 | −2342776.07 (2218938.56) | −6724753.89 to 2039201.76, 0.29 | −2451545.36 (2231240.70) | −6858237.29 to 1955146.56, 0.27 |
20 000 | −4684372.93 (4437920.28) | −13448413.80 to 4079667.94, 0.29 | −4901420.22 (4462481.46) | −13714804.20 to 3911963.77, 0.27 |
30 000 | −7025969.80 (6656902.01) | −20172073.70 to 6120134.15, 0.29 | −7351295.08 (6693722.26) | −20571371.20 to 5868871.04, 0.27 |
40 000 | −9367566.66 (8875883.74) | −26895733.70 to 8160600.36, 0.29 | −9801169.94 (8924963.07) | −27427938.20 to 7825598.33, 0.27 |
50 000 | −11709163.50 (11094865.47) | −33619393.60 to 10201066.58, 0.29 | −12251044.80 (11156203.89) | −34284505.20 to 9782415.63, 0.27 |
60 000 | −14050760.40 (13313847.20) | −40343053.60 to 12241532.79, 0.29 | −14700919.70 (13387444.70) | −41141072.20 to 11739232.93, 0.27 |
70 000 | −16392357.30 (15532828.94) | −47066713.50 to 14281999.01, 0.29 | −17150794.50 (15618685.51) | −47997639.20 to 13696050.23, 0.27 |
80 000 | −18733954.10 (17751810.67) | −53790373.50 to 16322465.23, 0.29 | −19600669.40 (17849926.33) | −54854206.30 to 15652867.53, 0.27 |
90 000 | −21075551.00 (19970792.40) | −60514033.40 to 18362931.44, 0.29 | −22050544.20 (20081167.14) | −61710773.30 to 17609684.84, 0.27 |
100 000 | −23417147.90 (22189774.14) | −67237693.40 to 20403397.66, 0.29 | −24500419.10 (22312407.96) | −68567340.30 to 19566502.14, 0.27 |
(B) QALY | ||||
---|---|---|---|---|
WTP‡ | Healthcare payer† | Societal† | ||
Incremental net benefit | 95% CI, p value | Incremental net benefit | 95% CI, p value | |
0 | −2020.18 (558.61) | −3123.38 to −916.98, <0.01 | −2048.89 (946.17) | −3917.66 to −180.11, 0.03 |
1500 | −2226.59 (608.74) | −3427.75 to −1023.38, <0.01 | −2250.38 (1006.93) | −4239.15 to −261.59, 0.03 |
2000 | −2294.02 (645.94) | −3569.69 to −1018.34, <0.01 | −2317.54 (1039.73) | −4371.10 to −263.98, 0.03 |
2500 | −2362.48 (691.03) | −3727.19 to −997.77, <0.01 | −2384.70 (1077.94) | −4513.73 to −255.67, 0.03 |
5000 | −2704.77 (991.35) | −4662.60 to −746.96, 0.01 | −2720.52 (1331.67) | −5350.69 to −90.34 0.04 |
10 000 | −3389.38 (1735.70) | −6817.21 to 38.45, 0.05 | −3392.14 (2007.52) | −7357.19 to 572.91, 0.09 |
20 000 | −4758.57 (3339.13) | −11353.01 to 1835.87, 0.16 | −4735.40 (3560.87) | −11768.45 to 2297.66, 0.18 |
30 000 | −6127.77 (4972.26) | −15947.50 to 3691.96, 0.22 | −6078.65 (5181.15) | −16311.90 to 4154.60, 0.24 |
40 000 | −7496.98 (6613.14) | −20557.26 to 5563.32, 0.26 | −7452.72 (6820.82) | −20893.66 to 6049.85, 0.28 |
50 000 | −8866.17 (8257.13) | −25173.19 to 7440.86, 0.29 | −8765.16 (8468.63) | −25491.49 to 7961.16, 0.30 |
60 000 | −10235.37 (9902.70) | −29792.22 to 9321.50, 0.30 | −10108.42 (10120.60) | −30097.54 to 9880.70, 0.32 |
70 000 | −11604.56 (11549.16) | −34413.03 to 11203.90, 0.32 | −11451.68 (11774.98) | −34708.34 to 11804.99, 0.33 |
80 000 | −12973.76 (13196.19) | −39034.94 to 13087.42, 0.33 | −12794.93 (13430.88) | −39322.15 to 13732.30, 0.34 |
90 000 | −14342.96 (14843.59) | −43657.60 to 14971.67, 0.34 | −14138.19 (15087.81) | −43937.98 to 15661.62, 0.35 |
100 000 | −15712.16 (16491.26) | −48280.77 to 16856.45, 0.34 | −15481.44 (16745.45) | −48555.23 to 17592.53, 0.36 |
*WTP for a one-point improvement on the WOMAC total score.
†Incremental net benefit (SE).
‡WTP for an additional QALY.
QALY, quality-adjusted life year; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index; WTP, willingness-to-pay.