Differences in central arterial function associated with the use of non-selective non-steroidal anti-inflammatory drugs
| Unadjusted mean difference (95% CI) | p Value | Adjusted mean difference (95% CI) | p Value | Summary of model | |||||
| R | Adj R2 | p Value (ANOVA) | |||||||
| Augmentation index (AIX%) | |||||||||
| Diclofenac | Reference group | ||||||||
| Naproxen/nabumetone | 1.7 | (−2.8 to 6.1) | 0.46 | 1.7 | (−2.0 to 5.4) | 0.35 | 0.70 | 0.40 | 0.0003 |
| Indomethacin | −1.6 | (−7.7 to 4.5) | 0.59 | −1.0 | (−7.8 to 5.8) | 0.77 | 0.65 | 0.28 | 0.02 |
| Ibuprofen | −8.6 | (−15.9 to −1.2) | 0.02 | −6.5 | (−11.9 to −1.0) | 0.02 | 0.86 | 0.67 | 0.000001 |
| Reflected wave transit (RWT), ms | |||||||||
| Diclofenac | Reference group | ||||||||
| Naproxen/nabumetone | 1.9 | (−3.9 to 7.7) | 0.52 | 1.3 | (−4.5 to 7.0) | 0.66 | 0.54 | 0.16 | 0.05 |
| Indomethacin | 3.8 | (−3.0 to 10.6) | 0.26 | 3.5 | (−4.8 to 11.7) | 0.40 | 0.56 | 0.14 | 0.13 |
| Ibuprofen | 18.2 | (9.8 to 26.6) | 0.0001 | 14.2 | (6.3 to 22.2) | 0.001 | 0.82 | 0.59 | 0.00001 |
Adjusted using multiple linear regression (MLR) for age, sex, mean arterial blood pressure, ever smoked, Stanford HAQ score and cumulative erythrocyte sedimentation rate (ESR)-years.