Table 2

Risk of idiopathic sudden sensorineural hearing loss for cohort patients

	GSD^[+]				GSD^[−] (controls)
Characteristic	n	ISSNHL	PY	Rate	n	ISSNHL	PY	Rate^@	IRR (95% CI)	p Value
All	26 449	176	189 762.67	9.27	52 898	256	392 452.13	6.52	1.42 (1.17 to 1.72)	<0.01
Age (years)
0–35	4408	10	33 771.12	2.96	8786	15	67 618.38	2.22	1.33 (0.60 to 2.97)	0.48
35–49	7476	49	56 506.78	8.67	14 769	59	113 728.54	5.19	1.67 (1.14 to 2.44)	<0.01
50–64	7397	75	53 703.59	13.97	14 864	96	110 438.46	8.69	1.61 (1.19 to 2.17)	<0.01
≥65	7168	42	45 781.18	9.17	14 479	86	100 666.74	8.54	1.07 (0.74 to 1.55)	0.71
Gender
Male	12 003	92	83 915.80	10.96	23 931	121	175 626.39	6.89	1.59 (1.21 to 2.09)	<0.01
Female	14 446	84	105 846.87	7.94	28 967	135	216 825.73	6.23	1.27 (0.97 to 1.67)	<0.01
Comorbidity
DM	2685	26	17 290.34	15.04	5370	53	36 867.12	14.38	1.05 (0.65 to 1.67)	0.85
HTN	5832	49	38 574.89	12.70	11 837	87	82 499.32	10.55	1.20 (0.85 to 1.71)	0.30
Hch	1675	14	11 262.61	12.43	3300	24	22 701.60	10.57	1.18 (0.61 to 2.27)	0.63
Follow-up years
<1	26 449	24	25 973.96	9.24	52 898	30	52 645.13	5.70	1.62 (0.95 to 2.77)	0.08
1–2	25 692	48	50 597.40	9.49	52 413	56	103 949.84	5.39	1.76 (1.20 to 2.59)	<0.01
3–4	24 959	41	47 716.27	8.59	51 532	59	98 902.66	5.97	1.44 (0.97 to 2.15)	0.07
≥5	21 223	63	65 475.03	9.62	44 186	111	136 954.49	8.10	1.19 (0.87 to 1.62)	0.28

^@Rate: per 10 000 PY.
DM, diabetes mellitus; GSD^[+]/[−], [with]/[without] gallstone disease; Hch, hypercholesterolaemia; HTN, hypertension; IRR, incidence rate ratio; ISSNHL, idiopathic sudden sensorineural hearing loss; PY, person-years.