Variables associated with significant fibrosis in the estimation cohort
| Variable | S0–1 (n=207) | S2–4 (n=46) | p Value |
|---|---|---|---|
| Age (years) | 37.2±9.8 | 38.9±10.8 | 0.288 |
| Male, n (%) | 132 (63.8) | 34 (73.9) | 0.190* |
| BMI (kg/m2) | 22.6±3.26 | 22.2±4.28 | 0.316 |
| WCC (109/L) | 5.46±1.49 | 5.53±2.10 | 0.773 |
| RBC (1012/L) | 4.81±0.50 | 4.76±0.59 | 0.536 |
| Hgb (g/L) | 148±19 | 144±19 | 0.238 |
| RDW (%) | 13.0±1.1 | 13.5±1.5 | 0.021 |
| PLT (109/L) | 189±53 | 150±55 | <0.001 |
| TP (g/L) | 73.1±6.3 | 70.0±7.7 | 0.006 |
| ALB (g/L) | 45.9±4.8 | 42.5±6.2 | <0.001 |
| TBIL (μmol/L) | 13 (4–69) | 14 (4–436) | 0.857† |
| AST (U/L) | 30 (14–429) | 31 (16–479) | 0.458† |
| ALT (U/L) | 45 (8–379) | 40 (8–569) | 0.759† |
| GGT (U/L) | 24 (7–175) | 37 (10–586) | <0.001† |
| ALP (U/L) | 68 (29–169) | 75 (36–184) | 0.044† |
| FPG (mmol/L) | 4.60±0.52 | 4.83±1.77 | 0.159 |
| TG (mmol/L) | 1.03 (0.42–9.41) | 0.88 (0.39–2.88) | 0.032† |
| Tch (mmol/L) | 4.62±0.95 | 3.79±1.10 | <0.001 |
| PT (s) | 11.5±0.8 | 12.9±4.4 | <0.001 |
| APTT (s) | 27.4±4.3 | 31.7±8.1 | <0.001 |
| Fbg (g/L) | 2.34±0.58 | 2.17±0.82 | 0.103 |
| AFP (ng/mL) | 3.2 (1.0–20.7) | 4.8 (0.8–644.3) | 0.034† |
| HBeAg status, n (%) | 117 (56.5) | 25 (54.3) | 0.788* |
*p Values are comparisons between S0–1 and S2–4 using an independent samples t test, except using the χ2 test.
†p Values are comparisons between S0–1 and S2–4 using an independent samples t test, except using the Mann-Whitney U test.
AFP, α-fetal protein; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; APTT, activated partial thromboplastin time; AST, aspartate aminotransferase; BMI, body mass index; Fbg, fibrinogen; FPG, fasting plasma glucose; GGT, γ-glutamyl transpeptidase; HBeAg, hepatitis B e antigen; Hgb, haemoglobin; PLT, platelet count; PT, prothrombin time; RBC, red blood cell; RDW, red cell distribution width; TBIL, total bilirubin; Tch, total cholesterol; TG, triglyceride; TP, total protein; WCC, white cell count.