Summary of non-invasive indices for predicting significant liver fibrosis
| Index | Formula |
|---|---|
| AAR8 | AST/ALT |
| FIB-411 | (Age×AST)/(PLT (109/L)×ALT1/2) |
| Forns index10 | 7.811–3.131×LN(PLT)+0.781×LN(GGT)+3.467×LN(age)−0.014×Tch |
| APRI9 | ((AST/ULN)/PLT (109/L))×100 |
| Fibro Q12 | (10×age×AST×PT INR)/(PLT×ALT) |
| APGA13 | Log(index)=1.44+0.1490×log(GGT)+0.3308×log(AST)−0.5846×log(PLT)+0.1148×log (AFP+1) |
| PAPAS14 | Log(index+1)=0.0255+0.0031×age+0.1483×log(ALP)−0.004×log(AST)+0.0908×log(AFP+1)−0.028×log (PLT) |
| GUCI15 | ((AST/ULN)×prothrombin-INR)×100/PLT |
| RPR16 | RDW/PLT |
| GP17 | GLOB×100/PLT |
Units of AST, ALT, GGT and ALP: U/L; units of age, Tch, AFP, GLOB, PLT and RDW: years, mmol/L, ng/mL, g/dL, 109/L and %, respectively.
AAR, AST to ALT ratio; AFP, α-fetal protein; ALP, alkaline phosphatase; ALT, alanine aminotransferase; APGA, AFP index; APRI, AST to platelet ratio index; AST, aspartate aminotransferase; FIB-4, INR index; GGT, γ-glutamyl transpeptidase; GLOB, globulin; GP, globulin-platelet model; GUCI, Göteborg University Cirrhosis Index; INR, international normalised ratio; PAPAS, AST index; PT, prothrombin time; PLT, platelet count; RDW, red cell distribution width; RPR, RDW to platelet ratio; Tch, total cholesterol; ULN, upper limit of normal.