HRs for all outcomes by patterns of high BMI at mean ages 21 and 50 years
| BMI trajectory | N | BMI-21 mean (SD) | BMI-50 mean (SD) | Diabetes HR (95% CI) | MI HR (95% CI) | Stroke HR (95% CI) | Fatal MI HR (95% CI) | Fatal HR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| 0–0 | 3055 | 20.6 (1.7) | 23.9 (2.1) | 1 | 1 | 1 | 1 | 1 |
| 1–0 | 637 | 24.9 (1.7) | 25.2 (1.6) | 0.81 (0.60 to 1.08) | 0.95 (0.78 to 1.17) | 0.81 (0.62 to 1.08) | 1.05 (0.81 to 1.38) | 0.65 (0.38 to 1.12) |
| 0–1 | 574 | 21.2 (1.9) | 29.3 (2.0) | 3.02 (2.45 to 3.73)a | 1.63 (1.37 to 1.95)a | 1.25 (0.98 to 1.60) | 1.80 (1.44 to 2.26)a | 1.12 (0.72 to 1.74) |
| 1–1 | 576 | 26.2 (2.9) | 29.9 (2.2) | 2.84 (2.32 to 3.48)a | 1.28 (1.06 to 1.56)b | 1.01 (0.77 to 1.32) | 1.51 (1.17 to 1.94)b | 0.92 (0.56 to 1.53) |
For BMI-21 and BMI-50, this includes all available data.
BMI trajectories: the values 0 and 1 denote BMI below and above the 75th centile, respectively. Each couple of zeros and ones corresponds to different trajectories of high BMI in early and middle adulthood.
HR comparing the risk of cardiovascular outcome in different trajectories of BMI with the 0–0 reference group. Estimates are adjusted for age and smoking in middle adulthood and town (fixed effect).
ap<0.001, bp<0.05.
BMI, body mass index; MI, myocardial infarction; N, total number of participants.