Odds of recruitment relative to exclusion overall (for all patients screened), and odds of recruitment relative to a specific reason for non-recruitment (subgroup analysis), according to age, gender, stroke type and severity*
| Recruited versus non-recruited due to | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Recruited versus non-recruitment (n=20 000) | After 24 h (n=8881) | mRS≥3 (n=4467) | ICU admit (n=2067) | Deteriorated (n=2796) | Coronary condition (n=1571) | Failed physiological (n=2397) | Other trial (n=1574) | Other (n=6068) | Refused (n=1442) | Missed (n=5944) | |
| Older age, years | |||||||||||
| OR | 0.99 | 1 | 0.94 | 1.04 | 0.96 | 0.99 | 1 | 1 | 1 | 1 | 0.99 |
| 95% CI | 0.99 to 1.00 | 0.99 to 1.00 | 0.93 to 0.94 | 1.03 to 1.05 | 0.95 to 0.97 | 0.98 to 1.00 | 0.99 to 1.01 | 0.99 to 1.01 | 0.99 to 1.00 | 0.99 to 1.01 | 0.99 to 1.00 |
| p Value | <0.01 | 0.37 | <0.01 | <0.01 | <0.01 | 0.05 | 0.44 | 0.55 | 0.61 | 0.92 | 0.01 |
| Female | |||||||||||
| OR | 0.67 | 0.67 | 0.47 | 0.89 | 0.57 | 0.76 | 0.64 | 0.85 | 0.68 | 0.67 | 0.73 |
| 95% CI | 0.59 to 0.76 | 0.59 to 0.77 | 0.41 to 0.56 | 0.69 to 1.15 | 0.45 to 0.72 | 0.58 to 0.99 | 0.52 to 0.79 | 0.65 to 1.12 | 0.59 to 0.78 | 0.50 to 0.89 | 0.63 to 0.84 |
| p Value | <0.01 | <0.01 | <0.01 | 0.370 | <0.01 | 0.038 | <0.01 | 0.251 | <0.01 | 0.01 | <0.01 |
| Haemorrhagic stroke | |||||||||||
| OR | 0.93 | 1.06 | 1.15 | 0.28 | 0.30 | 1.55 | 0.64 | 1.82 | 1.26 | 1.10 | 1 |
| 95% CI | 0.77 to 1.12 | 0.87 to 1.29 | 0.90 to 1.46 | 0.21 to 0.38 | 0.23 to 0.41 | 1.01 to 2.37 | 0.49 to 0.84 | 1.19 to 2.79 | 1.02 to 1.56 | 0.70 to 1.74 | 0.81 to 1.24 |
| p Value | 0.45 | 0.56 | 0.26 | <0.01 | <0.01 | 0.04 | 0.001 | 0.01 | 0.03 | 0.68 | 0.97 |
| More severe stroke | |||||||||||
| OR | 0.94 | 1.31 | 0.61 | 0.23 | 0.11 | 0.54 | 0.47 | 0.91 | 1.07 | 1.10 | 1.08 |
| 95% CI | 0.87 to 1.02 | 1.20 to 1.43 | 0.55 to 0.68 | 0.19 to 0.27 | 0.09 to 0.13 | 0.45 to 0.63 | 0.42 to 0.54 | 0.76 to 1.09 | 0.97 to 1.17 | 0.90 to 1.35 | 1.00 to 1.18 |
| p Value | 0.16 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | 0.32 | 0.19 | 0.35 | 0.14 |
Each cell indicates whether patients with a specific demographic factor are more/less likely to be recruited rather than fall into a particular exclusion category. Scores over 1 indicate that a patient is more likely to be recruited than be excluded for the reason identified (eg, patients with severe stroke are more likely to be recruited than arrive late), while scores under 1 indicate that a patient is less likely to be recruited than fall into that particular exclusion category (eg, female patients are less likely to be recruited than to arrive late).
Severity of stroke is based on an NIHSS estimate of mild, moderate or severe.
Grey cells indicate OR<1, p<0.05.
Bold cells indicate OR>1, p<0.05.
*Adjusted for time (month of trial).
ICU, intensive care unit; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale.